中国中药杂志2025，Vol.50Issue(23)：6605-6615,11.DOI:10.19540/j.cnki.cjcmm.20250815.201
淫羊藿及复方治疗抑郁症作用机制特点分析
Mechanism and characteristics of Epimedii Folium and its compound preparations in treatment of depression
摘要
Abstract
Depression is a common mental disorder in clinical practice,and its clinical manifestations can be classified under the category of ″Yubing″ in traditional Chinese medicine(TCM).According to TCM theory,the onset of depression is closely related to emotional imbalance,disharmony of Qi and blood,and dysfunction of internal organs.Among them,deficiency of kidney Yang syndrome is one of the important syndromes of depression.Modern research shows that the pathogenesis of depression is complex,involving hypothalamic-pituitary-adrenal(HPA)axis dysfunction,neuroinflammation,oxidative stress,and other mechanisms.Epimedii Folium is a classic TCM for tonifying Yang,first recorded in the Shennong's Classic Materia Medica.It has the functions of tonifying kidney Yang and dispelling rheumatism.Its bioactive components are complex,mainly including flavonoids,polysaccharides,and alkaloids,which exert pharmacological effects such as neuroprotection,anti-inflammation,antioxidation,anti-tumor,and anti-osteoporosis activities.In recent years,an increasing number of studies have focused on the pharmacological effects and molecular mechanisms of Epimedii Folium in the treatment of depression.Studies have shown that Epimedii Folium can exert antidepressant effects by regulating the levels of neurotransmitters and the function of the HPA axis,reducing inflammatory responses,and alleviating oxidative stress.In addition,Epimedii Folium can promote the expression of neurotrophic factors and improve synaptic plasticity of hippocampal neurons,thereby achieving antidepressant efficacy.Based on existing research,this article systematically summarized the chemical components of Epimedii Folium and reviewed the mechanism underlying its antidepressant effects,as well as those of its compound preparations,particularly in relation to HPA axis regulation and anti-inflammatory responses.These findings provide a more solid scientific basis for studying the pathogenesis of depression from multiple perspectives,improving the prevention and treatment of depression,and developing new drugs.关键词
淫羊藿/化学成分/抑郁症/复方/作用机制Key words
Epimedii Folium/chemical constituent/depression/compound preparation/mechanism of action引用本文复制引用
WANG Rui-ying,GUO Lin,WANG Hao-yang,QIU Shu-xuan,ZUO Yuan,CAO Li-hua,MIAO Ming-san..淫羊藿及复方治疗抑郁症作用机制特点分析[J].中国中药杂志,2025,50(23):6605-6615,11.基金项目
国家自然科学基金面上项目(82274119) （82274119）
河南省重点研发专项(251111310400) （251111310400）
河南重大科技专项(221100310500) （221100310500）
河南省中医药科学研究重大专项(2024ZYZD15) （2024ZYZD15）
河南省中医学"双一流"创建科学研究专项(HSRP-DFCTCM-2023-1-14) （HSRP-DFCTCM-2023-1-14）
河南省"双一流"创建学科中医学科学研究专项(HSRP-DFCTCM-2023-8-09) （HSRP-DFCTCM-2023-8-09）
河南省科技攻关项目(242102311291) （242102311291）
河南省高等学校重点科研项目(25CY021) （25CY021）
河南省重大公益专项(201300310100) （201300310100）
