中国医学前沿杂志（电子版）2025，Vol.17Issue(12)：12-18,7.DOI:10.12037/YXQY.2025.12-03
癫痫发作的神经电生理机制与时空动态结构
Neuroelectrophysiological mechanisms and spatiotemporal dynamics of epileptic seizure
Zhang Xiaolei 1Long Qiting 2Wu Zhe 2Feng Xinhong 2Zhang Wei2
作者信息
- 1. Department of Neurosurgery,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua Medicine,Tsinghua University,Beijing 102218,China
- 2. Department of Neurology,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua Medicine,Tsinghua University,Beijing 102218,China
- 折叠
摘要
Abstract
Epileptic seizures are transient cerebral dysfunctions caused by abnormal discharges resulting from an imbalance between excitation and inhibition.The interaction between excitatory and inhibitory neurons,particularly the central role of inhibitory interneurons through mechanisms such as γ-aminobutyric acid signaling,disruption of chloride ion homeostasis,and potassium diffusion,is crucial in the initiation,propagation,and termination of seizures.Epileptic seizures exhibit a"dual"structure composed of an ictal core and a penumbra,and undergo a temporal evolution process including recruitment,propagation,and termination.The combined use of macroelectrodes and microelectrodes provides a cross-scale perspective for understanding epileptic dynamics,offering significant insights for precise surgical interventions.关键词
癫痫发作/抑制性中间神经元/时空动态/宏电极/微电极Key words
Epileptic seizure/Inhibitory interneurons/Spatiotemporal dynamics/Macroelectrode/Microelectrode引用本文复制引用
Zhang Xiaolei,Long Qiting,Wu Zhe,Feng Xinhong,Zhang Wei..癫痫发作的神经电生理机制与时空动态结构[J].中国医学前沿杂志（电子版）,2025,17(12):12-18,7.
