中国医学前沿杂志（电子版）2025，Vol.17Issue(12)：19-28,10.DOI:10.12037/YXQY.2025.12-04
外泌体调节神经免疫反应治疗癫痫的作用机制研究进展
Advances in the mechanisms by which exosomes modulate neuroimmune responses for the treatment of epilepsy
摘要
Abstract
Epilepsy is a chronic neurological disorder that imposes a substantial burden on public health and quality of life.Etiologically,it can be classified into structural,genetic,metabolic,infectious,and immune-related subtypes.Growing evidence highlights the pathogenic contribution of neuroinflammation to epileptogenesis.Anti-seizure medications(ASMs)remain the mainstay of therapy;however,approximately 30%of patients are pharmacoresistant to ASMs with diverse mechanisms of action,meaning they are unable to effectively control their epileptic seizures.Recent studies have identified exosomes as promising therapeutic vehicles capable of modulating inflammatory and immune responses.Exosomes may attenuate epileptic seizure burden by mediating immune reactions and mitigating neuroinflammation.This review summarizes current understanding of the neuroimmune mechanisms underlying epilepsy and delineates recent advances in exosome-mediated immunomodulation of neuroinflammation,thereby providing a theoretical framework and practical guidance for future research and clinical translation.关键词
癫痫/外泌体/神经炎症/细胞因子/免疫调节/作用机制Key words
Epilepsy/Exosomes/Neuroinflammation/Cytokines/Immunomodulation/Mechanism引用本文复制引用
Zhang Jie,Feng Shuo,Chen Qian..外泌体调节神经免疫反应治疗癫痫的作用机制研究进展[J].中国医学前沿杂志（电子版）,2025,17(12):19-28,10.基金项目
Beijing Hospitals Authority Innovation Studio of Young Staff Funding Support(202129) 北京市医院管理中心创新梦工厂经费资助(202129) （202129）
