中国医学前沿杂志（电子版）2025，Vol.17Issue(12)：53-57,5.DOI:10.12037/YXQY.2025.12-09
多聚ADP-核糖聚合酶家族成员14在系统性红斑狼疮中的研究
A review of research on poly(adp-ribose)polymerase family member 14 in systemic lupus erythematosus
摘要
Abstract
Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by aberrant activation of the type I interferon signaling pathway and excessive production of pathogenic autoantibodies.Recent studies have revealed that ADP-ribosylation modification regulates immune processes such as T lymphocyte differentiation and B cell antibody secretion.poly(adp-ribose)polymerase family member 14,a multifunctional ADP-ribosyl transferase,not only dynamically modifies target biomolecules including proteins,DNA,and RNA through mono-ADP-ribosylation but also plays a critical role in DNA damage repair,inflammatory regulation,and maintenance of immune homeostasis.This review systematically summarizes the molecular mechanisms by which PARP14 influences the pathogenesis and progression of SLE through epigenetic and immunoregulatory pathways.关键词
多聚ADP-核糖聚合酶家族成员14/ADP-核糖基化/系统性红斑狼疮Key words
Poly(ADP-ribose)polymerase family member 14/ADP-ribosylation/Systemic lupus erythematosus引用本文复制引用
Xia Qingyue,Xu Jingkai,Cui Yong..多聚ADP-核糖聚合酶家族成员14在系统性红斑狼疮中的研究[J].中国医学前沿杂志（电子版）,2025,17(12):53-57,5.基金项目
National Key Research and Development Program(2022YFC3602002) （2022YFC3602002）
Fundamental Research Funds for the Central Universities,Peking Union Medical College(3332025170) 国家重点研发专项(2022YFC3602002) （3332025170）
北京协和医学院中央高校基本科研业务费专项资金(3332025170) （3332025170）
