中国中药杂志2025，Vol.50Issue(24)：6781-6796,16.DOI:10.19540/j.cnki.cjcmm.20250728.302
中医药调控NF-κB相关信号通路干预慢性胃炎"炎癌转化"研究进展
Research progress on intervention of"inflammation-cancer transformation"of chronic gastritis through regulation of NF-κB-related signaling pathways by traditional Chinese medicine
摘要
Abstract
Chronic gastritis,a chronic and insidious inflammatory condition of the gastric mucosa,is characterized by nonspecific early symptoms and a high risk of progression to gastric cancer.Persistent inflammatory stimulation accelerates the"inflammation-cancer transformation"by remodeling the microenvironment,and suppressing this process is critical for gastric cancer prevention and treatment.Nuclear factor-κB(NF-κB)serves not only as a central hub for inflammatory regulation but also as a key node connecting pathways such as Toll-like receptor 4(TLR4),NOD-like receptor protein 3(NLRP3),mitogen-activated protein kinase(MAPK),signal transducer and activator of transcription 3(STAT3),and protein kinase B(AKT).Extensive studies have demonstrated that monomers and herbal formulas in traditional Chinese medicine(TCM)can modulate NF-κB-related signaling pathways to mitigate the progression of"inflammation-cancer transformation"of chronic gastritis,achieving multi-level,multi-target intervention in gastric cancer.Based on this,this article systematically reviewed the dynamic network of NF-κB and relevant crosstalk pathways in"inflammation-cancer transformation"and the mechanisms of TCM-based interventions,providing theoretical foundations for optimizing clinical strategies and advancing gastric cancer prevention.关键词
慢性胃炎/胃癌/炎癌转化/NF-κB/中医药Key words
chronic gastritis/gastric cancer/inflammation-cancer transformation/NF-κB/traditional Chinese medicine(TCM)引用本文复制引用
ZHUANG Yan,DU Yu-jia,CUI Ming-xuan,MIAO Jun-hao,YU Chun-yue..中医药调控NF-κB相关信号通路干预慢性胃炎"炎癌转化"研究进展[J].中国中药杂志,2025,50(24):6781-6796,16.基金项目
国家自然科学基金青年基金项目(82104819) （82104819）
