肿瘤药学2025，Vol.15Issue(5)：582-588,7.DOI:10.3969/j.issn.2095-1264.2025.05.03
放疗在驱动基因阴性晚期非小细胞肺癌中的作用
The role of radiotherapy in advanced driver gene-negative non-small cell lung cancer
摘要
Abstract
Lung cancer remains the leading cause of cancer-related mortality worldwide,with non-small cell lung can-cer(NSCLC)constituting the majority of cases.Radiotherapy plays a pivotal role in the multidisciplinary management of ad-vanced NSCLC,particularly for patients with driver gene-negative tumors.Significant technological advancements in radio-therapy,coupled with the development of novel therapies such as immune checkpoint inhibitors(ICIs),have transformed its role from a purely palliative modality to a key treatment capable of improving survival.This article systematically reviews the three primary applications of radiotherapy in driver gene-negative advanced NSCLC:palliative treatment,management of oligometastatic disease,and brain metastasis control.It also provides an in-depth discussion of the synergistic mecha-nisms,clinical efficacy,and safety profile of combining radiotherapy with immunotherapy.关键词
非小细胞肺癌/放射治疗/寡转移/脑转移/免疫检查点抑制剂/驱动基因阴性Key words
Non-small cell lung cancer/Radiotherapy/Oligometastasis/Brain metastasis/Immune checkpoint inhibi-tors/Driver gene-negative分类
医药卫生引用本文复制引用
CHEN Lingjuan..放疗在驱动基因阴性晚期非小细胞肺癌中的作用[J].肿瘤药学,2025,15(5):582-588,7.基金项目
国家自然科学基金青年项目(82403067). （82403067）
