中国肿瘤外科杂志2025，Vol.17Issue(6)：532-539,8.DOI:10.3969/j.issn.1674-4136.2025.06.002
肿瘤异常能量代谢对肿瘤免疫微环境的调控及其干预研究进展
Regulation of the tumor immune microenvironment by aberrant tumor metabolism and strategies for intervention
摘要
Abstract
Malignant tumors pose a severe threat to human health and have emerged as a major global public health challenge.Compared with healthy individuals,cancer patients often exhibit a hypermetabolic state and metabolic disorders,which originate from the complex metabolic reprogramming of cancer cells.This process not only provides the necessary bioenergy and biosynthetic precursors for the rapid proliferation,invasion,and metastasis of cancer cells but also profoundly remodels the tumor immune microenvironment(TIME),leading to impaired immune surveillance and subsequent promotion of immune evasion and cancer progression.Therefore,in-depth investigation into the regulatory mechanisms of aberrant tumor energy metabolism on the immune microenvironment and potential therapeutic interventions has become a cutting-edge focus in current cancer research.This article systematically reviews recent advances,aiming to provide a theoretical foundation for novel anti-tumor therapeutic strategies targeting the"metabolism-immune"axis.关键词
代谢重编程/肿瘤异常能量代谢/肿瘤免疫微环境/免疫逃逸/代谢干预Key words
Tumor metabolic reprogramming/Aberrant Tumor Metabolism/Tumor microenvironment/Tumor immune escape/Metabolic intervention引用本文复制引用
HUANG Shiyu,SU Xiangyu..肿瘤异常能量代谢对肿瘤免疫微环境的调控及其干预研究进展[J].中国肿瘤外科杂志,2025,17(6):532-539,8.基金项目
中国医药卫生事业发展基金会肿瘤转化医学科研公益项目(chmdf2024-xrzx04-04) （chmdf2024-xrzx04-04）
东南大学附属中大医院江苏省高水平医院建设经费资助(GSP-LCYJFH14) （GSP-LCYJFH14）
