中国肿瘤外科杂志2025，Vol.17Issue(6)：540-547,8.DOI:10.3969/j.issn.1674-4136.2025.06.003
肿瘤葡萄糖代谢的研究现状及进展
Current status and advances in tumor glucose metabolism research
摘要
Abstract
Even under oxygen-rich conditions,tumor cells preferentially utilize aerobic glycolysis for energy production—a phenomenon known as the"Warburg effect".Originally regarded as a metabolic anomaly,this effect is now recognized as a central adaptive strategy that drives tumorigenesis,immune evasion,metastasis,and therapeutic resistance.This review summarizes recent advances in tumor glucose metabolism research across four key dimensions.Basic mechanisms:The Warburg effect is redefined as a survival program that supports biosynthesis,redox homeostasis,and signaling,orchestrated by oncogenes(e.g.,c-Myc,HIF-1α),tumor suppressors(e.g.,p53,PTEN),and the microenvironment,and integrated with epigenetic regulation via metabolites such as acetyl-CoA and α-ketoglutarate;Immune microenvironment modulation:Tumor-associated macrophages(TAMs)undergo metabolic reprogramming toward an M2-like phenotype,where lactate,acetyl-CoA,and O-GlcNAcylation act as key mediators to establish an immunosuppressive niche;Metastasis promotion:Excessive glucose restriction can induce metabolic stress,triggering neuroendocrine-like programs and epithelial-mesenchymal transition(EMT),paradoxically enhancing lung metastasis;Clinical translation:Inhibitors targeting critical nodes—such as GLUT1,HK2,LDHA,monocarboxylate transporters(MCTs),and O-GlcNAc transferase(OGT)—are under development,with combination strategies involving immune checkpoint blockade,radiotherapy/chemotherapy,and targeted therapy showing promise.Future efforts should move beyond broad metabolic inhibition toward precision modulation of the"metabolism-signaling-immunity"axis.关键词
肿瘤/葡萄糖代谢/Warburg效应/代谢重编程Key words
Cancer/Glucose metabolism/Warburg effect/Metabolic reprogramming引用本文复制引用
WANG Lin..肿瘤葡萄糖代谢的研究现状及进展[J].中国肿瘤外科杂志,2025,17(6):540-547,8.基金项目
海南省卫生健康科技创新联合项目(SQ2026WSJK0218) （SQ2026WSJK0218）
