肿瘤药学2025，Vol.15Issue(5)：609-617,9.DOI:10.3969/j.issn.2095-1264.2025.05.06
铁死亡在肺癌治疗中相关机制的研究进展
Research progress on the mechanisms of ferroptosis in lung cancer treatment
摘要
Abstract
Lung cancer has become the most prevalent malignant tumor among all cancers worldwide in recent years.Currently,clinical treatment is facing a severe challenge of drug resistance,and there is an urgent need to develop new strategies to address this issue.Ferroptosis is a form of iron-dependent non-apoptotic cell death,which mainly involves the impairment of the antioxidant defense function of the system Xc--GPX4 pathway,the accumulation of lipid peroxidation,and the disorder of intracellular iron metabolism.Studies have shown that inducing ferroptosis can significantly enhance the sensitivity of tumor cells to conventional treatments in multiple lung cancer treatment fields,including radiotherapy,chemo-therapy,targeted therapy,and immunotherapy,thereby reversing drug resistance.Currently,some ferroptosis-related drugs and novel delivery systems have entered the clinical trial stage.In addition,the discovery of new natural ferroptosis agonists and the continuous clarification of their target sites have also provided new research directions and strategies for lung can-cer treatment.关键词
铁死亡/肺癌/耐药/铁死亡激动剂Key words
Ferroptosis/Lung cancer/Drug resistance/Ferroptosis agonist分类
医药卫生引用本文复制引用
LI Jingyi,ZENG Liang,ZHANG Yongchang,LI Kunyan..铁死亡在肺癌治疗中相关机制的研究进展[J].肿瘤药学,2025,15(5):609-617,9.基金项目
湖南省自然科学基金项目(2023JJ30368). （2023JJ30368）
