中国肿瘤外科杂志2025，Vol.17Issue(6)：548-557,10.DOI:10.3969/j.issn.1674-4136.2025.06.004
血液脂肪酸与晚期非小细胞肺癌患者血清白蛋白水平相关性研究
A Study on the Association Between Blood Fatty Acids and Serum Albumin Levels in Patients with Advanced Non-Small Cell Lung Cancer
摘要
Abstract
Objective Albumin(ALB)is a sensitive and routinely measured immunonutritional marker in malignancies,and nutritional and inflammatory status in cancer patients are closely associated with prognosis.This study aimed to investigate the association between blood fatty acid levels and serum ALB levels in patients with advanced non-small cell lung cancer(NSCLC),thereby providing a theoretical basis for precision nutritional interventions using omega-3 polyunsaturated fatty acids in cancer management.Methods A cross-sectional study was conducted,enrolling 110 patients who visited the First Medical Center of the General Hospital of the People's Liberation Army between June 2025 and November 2025.Data on participants'baseline characteristics,clinical information,laboratory test results,and fasting blood fatty acid profiles were collected.Participants were divided into four groups according to quartiles of ALB levels,and intergroup differences in blood fatty acids and other variables were compared.Univariate linear regression analyses were performed between ALB and each of the aforementioned variables.Variables showing statistical significance in the univariate analyses were subsequently included in a multivariate linear regression model to assess their independent associations with ALB.Results Significant intergroup differences were observed in palmitic acid,margaric acid,heptadecenoic acid,stearic acid,docosahexaenoic acid,pentadecanoic acid,palmitoleic acid,α-linolenic acid,eicosapentaenoic acid(EPA),the ω-3 polyunsaturated fatty acids(PUFAs)index,the ω-6 PUFAs/ω-3 PUFAs ratio,the arachidonic acid(AA)/EPA ratio,ω-3 PUFAs,vitamins A and B6,β2-microglobulin,and transferrin.Univariate linear regression analyses revealed that γ-linolenic acid and EPA were positively associated with ALB levels in patients with advanced NSCLC,whereas stearic acid,eicosenoic acid,erucic acid,nervonic acid,and the AA/EPA ratio were negatively associated with ALB.Multivariate linear regression analysis further identified EPA and the AA/EPA ratio as independent factors associated with ALB levels in these patients:EPA showed a positive association(P=0.004),while the AA/EPA ratio exhibited a negative association(P＜0.001).Conclusions Blood EPA levels and the AA/EPA ratio were independently associated with serum ALB levels in patients with advanced NSCLC.Precision nutritional intervention through supplementation with EPA-containing compounds to elevate blood EPA levels may improve nutritional and inflammatory status,thereby potentially enhancing prognosis and prolonging survival in these patients.关键词
二十碳五烯酸/白蛋白/ω-3多不饱和脂肪酸/非小细胞肺癌/免疫营养Key words
Eicosapentaenoic acid/Albumin/Omega-3 polyunsaturated fatty acids/Non-small cell lung cancer/Immunonutrition引用本文复制引用
LIU Xiangrong,YANG Bo,ZHANG Xiaoling,FENG Jie,LIU Lu,LIU Yinghua..血液脂肪酸与晚期非小细胞肺癌患者血清白蛋白水平相关性研究[J].中国肿瘤外科杂志,2025,17(6):548-557,10.基金项目
国家卫生健康委医院管理研究所临床营养工作高质量发展研究项目(2025-1-Z-01) （2025-1-Z-01）
