肿瘤药学2025，Vol.15Issue(5)：630-639,10.DOI:10.3969/j.issn.2095-1264.2025.05.08
鞘内注射在非小细胞肺癌脑膜转移治疗中的研究进展与临床应用
Intrathecal chemotherapy for NSCLC leptomeningeal metastasis:advances and applications
摘要
Abstract
Leptomeningeal metastasis is a severe complication of advanced cancers such as lung and breast cancer.Due to the blood-brain barrier,systemic treatments are often ineffective,leading to poor prognosis.Intrathecal injection,as a local treatment method,bypasses the blood-brain barrier by delivering drugs directly to the subarachnoid space,thus increasing drug concentration in the central nervous system and reducing systemic toxicity.In addition to traditional chemotherapy drugs like methotrexate and cytarabine,newer agents such as pemetrexed,targeted therapies,and immune checkpoint inhibitors are being explored for intrathecal therapy,showing promising efficacy and safety in some patients.However,existing evidence is mainly based on small sample studies,and further prospective research is needed to validate their effectiveness and safety.This review aims to summarize the mechanisms,commonly used drugs,clinical advances,and efficacy of intrathecal injection in the treatment of leptomeningeal metastasis in non-small cell lung cancer.关键词
脑膜转移/鞘内注射/非小细胞肺癌/血脑屏障/临床应用Key words
Leptomeningeal metastasis/intrathecal chemotherapy/non-small cell lung cancer/blood-brain barrier/clinical application分类
医药卫生引用本文复制引用
LIAO Yi,YANG Dan,YAN Huan,ZENG Liang,ZHANG Yongchang..鞘内注射在非小细胞肺癌脑膜转移治疗中的研究进展与临床应用[J].肿瘤药学,2025,15(5):630-639,10.基金项目
湖南省自然科学基金项目(2023JJ30368). （2023JJ30368）
