安徽医科大学学报2025，Vol.60Issue(12)：2264-2272,9.DOI:10.19405/j.cnki.issn1000-1492.2025.12.009
哺乳动物不育系20样激酶2基因多态性与结直肠癌的关联分析
Association study between mammalian sterile 20-like kinase 2 SNPs and colorectal cancer
摘要
Abstract
Objective To explore the association between mammalian sterile 20-like kinase 2(MST2)gene poly-morphism and haplotype and the risk of colorectal cancer,rectal cancer,and colon cancer in the Han population in Baotou area by case-control association study.Methods A total of 390 patients with colorectal cancer diagnosed by pathology and 413 normal physical examination pop-ulation were collected,and 2 mL of peripheral blood was taken for subsequent gene genotyping.Single nucleotide polymorphisms(SNPs)of MST2 gene were screened according to the genetic polymorphism data of Chinese Han population provided by the NCBI-Hapmap database.Gene genoty-ping was performed by Taqman method.Logistic regression was used to calculate the association between each SNP and the risk of colorectal cancer,colon cancer,and rectal cancer under codominant,dominant,overdominant,and recessive genetic models.Results Five SNPs of MST2 gene were screened,namely rs11783149,rs10955176,rs7827435,rs4075986,rs3019295.Among them,SNP rs4075986 was associated with the risk of colorectal canc-er.Compared with the rs4075986 GG+AA genotype,carrying the AG genotype[OR(95％CI)=2.473(1.844-3.316)could increase the risk of colorectal cancer.Compared with the rs4075986 GG genotype,carrying the AG+AA genotype[OR(95％CI)=2.475(1.844-3.323)could increase the risk of colorectal cancer.SNP rs4075986 and rs3019295 were associated with the risk of rectal cancer.Compared with the rs4075986 GG+AA genotype,carrying the AG genotype[OR(95％CI)=3.411(2.387-4.874)]could increase the risk of rectal cancer.Compared with the rs3019295 GG+AA genotype,carrying the AG genotype[OR(95％CI)=0.706(0.501-0.996)]could reduce the risk of rectal cancer.SNP rs11783149 and rs4075986 were associated with the risk of colon cancer.Compared with the rs11783149 CC genotype,carrying the TT[OR(95％CI)=10.883(1.186-99.862)]and CT[OR(95％CI)=1.665(1.036-2.675)]genotype could increase the risk of colon cancer,respectively.Compared with the rs4075986 GG genotype,the AG+AA genotype[OR(95％CI)=1.824(1.262-2.638)]could increase the risk of colon cancer.Conclusion MST2 gene SNP rs3019295 AG genotype may be protective factor for rectal cancer.SNP rs11783149 CT and TT genotypes maybe risk factors for colon canc-er.SNP rs4075986 AG and AG+AA genotypes may be a common risk factors for colorectal cancer,rectal cancer and colon cancer.关键词
结直肠癌/哺乳动物不育系20样激酶2/单核苷酸多态性/基因分型/关联研究/Hippo信号通路Key words
colorectal cancer/mammalian sterile 20-like kinase 2/single nucleotide polymorphism/genotyping/association study/Hippo signaling pathway分类
医药卫生引用本文复制引用
王兴宇,马立聪,董文杰,高芳,贾彦彬..哺乳动物不育系20样激酶2基因多态性与结直肠癌的关联分析[J].安徽医科大学学报,2025,60(12):2264-2272,9.基金项目
内蒙古自然科学基金项目(编号:2021LHMS08010) （编号:2021LHMS08010）
包头医学院创新团队发展计划项目(编号:bycxtd-06) Natural Science Foundation of Inner Mongolia Autonomous Region(No.2021LHMS08010) （编号:bycxtd-06）
Innovation Team Development Plan Project of Baotou Medical College(No.bycxtd-06) （No.bycxtd-06）
