生物资源2025，Vol.47Issue(6)：542-550,9.DOI:10.14188/j.ajsh.20251010001
生物水凝胶仿生技术及其应用于口服药物递送的研究进展
Research progress on bionic technology of biohydrogels and its application in oral drug delivery
摘要
Abstract
Hydrogels share structural similarities with natural soft tissues in organisms.Through bionic technology,biological hydrogels can be endowed with features similar to the extracellular matrix(ECM),cell membranes,or other biological structures,and mimic the in vivo environment.They possess excellent biocompatibility and are widely used in drug delivery,tissue engineering,wound dressings,and biosensors.Especially in the field of oral drug delivery,bio-hy-drogels can achieve targeted drug release and enhanced absorption through their intelligent responsiveness(such as pH-,enzyme-,or ROS-responsive mechanisms)and functional biomimicry(including mucosal adhesion and targeted recogni-tion),thereby improving the bioavailability of drugs and reducing side effects.This paper systematically reviews recent re-search progress and applications of biological hydrogel bionic technology in oral drug delivery in vivo,and discusses the application strategies of these materials in addressing related biological issues such as targeting and controlled release.This article aims to integrate biological resources for the optimization and innovation of biological hydrogels,and provides theoretical basis and practical guidance from a biological perspective.关键词
生物水凝胶/药物递送/仿生技术/结构仿生/智能响应型仿生/功能型仿生Key words
biohydrogels/drug delivery/bionic technology/structural bionics/intelligent responsive bionics/func-tional bionics分类
农业科技引用本文复制引用
杨萌萌,杨海龙,黄赞..生物水凝胶仿生技术及其应用于口服药物递送的研究进展[J].生物资源,2025,47(6):542-550,9.基金项目
赣州市章贡区科技计划(2024RC04) （2024RC04）
江西省重点研发计划(20223BBG71008) （20223BBG71008）
江西省国际科技合作-重点项目(20232BBH80011) （20232BBH80011）
