生物资源2025，Vol.47Issue(6)：621-628,8.DOI:10.14188/j.ajsh.20250818001
粗、细型绒山羊绒毛细度的血浆代谢组学差异
Plasma metabolomics differences in wool fineness between coarse and fine cashmere goats
摘要
Abstract
To investigate key metabolites and pathways influencing cashmere fineness through comprehensive analy-sis of wool traits,skin histology,and plasma metabolomics in cashmere goats,wool fineness and length were measured in 400 eighteen-month-old female Liaoning cashmere goats from two non-inbred families(coarse-and fine-type).12 indi-viduals with consistent traits(6 per group)were selected for detailed study.Histological examination was used to deter-mine secondary-to-primary follicle ratio and secondary follicle density.Plasma metabolomics analysis was performed us-ing LC-MS.Significant difference in fiber diameter(P<0.05)was observed between groups,while fiber length,second-ary follicle density and secondary-to-primary follicle ratio showed no significant differences(P>0.05).Plasma metabolo-mics analysis identified 25 known differential metabolites(9 upregulated,16 downregulated),with significant alterations in melatonin,α-tocopherol and amino acids involved in lipid/energy metabolism(P<0.05).These metabolites were en-riched in six metabolic pathways,with melatonin and L-lysine appearing in multiple pathways.Melatonin,α-tocopherol and amino acids related to lipid and energy metabolism represent potential biomarkers for cashmere fineness regulation.关键词
绒山羊/绒毛细度/血液/代谢组学Key words
cashmere goat/wool fineness/blood/metabolomics分类
农业科技引用本文复制引用
魏建玮,马桂霞,韩迪,全治国,王春强,马巍..粗、细型绒山羊绒毛细度的血浆代谢组学差异[J].生物资源,2025,47(6):621-628,8.基金项目
国家绒毛用羊产业技术体系(CARS-39-10 （）
CARS-39-27) （）
辽宁省绒山羊养殖标准化示范区建设(SFQ11-14) （SFQ11-14）
辽宁省大学生创新创业项目(S2024101600063) （S2024101600063）
