南方医科大学学报2026，Vol.46Issue(1)：66-73,8.DOI:10.12122/j.issn.1673-4254.2026.01.07
糖尿病胫前色素斑的病理改变揭示血管-免疫异常
Pathological characteristics of pigmented pretibial patches and vascular-immune abnormalities in diabetic patients
摘要
Abstract
Objective To explore pathological and immune cell infiltration characteristics of pigmented pretibial patches in diabetic patients.Methods Forty-two diabetic patients undergoing thigh amputation at Tianjin Medical University Chu Hsien-I Memorial Hospital were enrolled.Before the operation,the pretibial skin of the patients were examined and sampled for HE and Masson staining.The thickness of the epidermis and the density of blood vessels in the dermis were compared between patients with and without pigmented pretibial patches.The expressions of VEGFA and VEGFR2 in the skin tissues were detected using Western blotting,and CD4+and CD8+cells and the CD4/CD8 ratio were analyzed with immunohistochemical staining.Results Compared with the patients without pigmented pretibial patches,the patients with pigmented pretibial patches showed obvious thickening of the epidermal spinous layer,irregular downward extension of the epidermal projections,hyperkeratosis,melanin deposition in the basal layer,increased capillaries in the dermis,and localized,well-defined inflammatory cell infiltration around the blood vessels.In pigmented pretibial patches group,Masson staining revealed irregular arrangement,thickening and hyaline degeneration of collagen fibers,significantly increased epidermal thickness and blood vessel density in the dermis,increased CD4+cells and the CD4/CD8 ratio,and reduced CD8+cells.Conclusion The pigmented pretibial patches in diabetic patients show obvious pathological changes possibly due to vascular and immune abnormalities.关键词
糖尿病胫前色素斑/糖尿病皮肤病/糖尿病并发症/血管-免疫异常Key words
pigmented pretibial patches/diabetic dermopathy/diabetic complications/vascular-immune abnormalities引用本文复制引用
刘信邦,常柏..糖尿病胫前色素斑的病理改变揭示血管-免疫异常[J].南方医科大学学报,2026,46(1):66-73,8.基金项目
国家自然科学基金(81973614)Supported by National Natural Science Foundation of China(81973614). （81973614）
