南方医科大学学报2026，Vol.46Issue(1)：83-93,11.DOI:10.12122/j.issn.1673-4254.2026.01.09
降脂祛斑方多成分协同调控炎症-代谢网络改善2型糖尿病合并高脂血症:网络药理学与临床验证
Jiangzhi Quban Recipe improves type 2 diabetes mellitus complicated with hyperlipidemia by multi-target regulation of the inflammation-metabolism network:network pharmacology analysis and clinical validation
摘要
Abstract
Objective To explore the therapeutic mechanism of Jiangzhi Quban Recipe(JZQBR)for type 2 diabetes mellitus(T2DM)complicated with hyperlipidemia and validate its clinical efficacy and safety.Methods The active components and disease targets of JZQBR were screened using TCMSP and GeneCards databases,followed by protein-protein interaction analysis and GO and KEGG enrichment analyses.In the animal experiments,ApoE-/-mice were randomized into blank control,model,simvastatin treatment,and low-and high-dose JZQBR groups.In the latter 4 groups,the mice were fed a high-fat diet for 24 weeks with corresponding treatments from Weeks 9 to 24.The changes in body weight,blood glucose,lipids,liver pathology,and inflammatory cytokine expressions of the mice were examined.In the clinical study,72 T2DM patients with hyperlipidemia were randomized equally into control group for treatment with metformin plus empagliflozin and JZQBR group with additional JZQBR for 12 consecutive weeks.Results Network pharmacology identified 65 potential targets,with quercetin,kaempferol,and luteolin as the core components and IL-6,IL-1β,and TNF-α as the key targets.The targets were enriched mainly in the pathways involving inflammatory responses and diabetic complications.In the ApoE-/-mouse models,JZQBR treatment dose-dependently improved body weight,blood glucose,and blood lipid profiles,and high-dose JZQBR produced a stronger effect than simvastatin for improving hepatic steatosis and significantly reduced inflammatory cytokine levels.In the clinical trial,29 patients in JZQBR group and 31 in the control group completed the trial.The patients in JZQBR group showed significant improvements in body weight,FBG,TG,HbA1c,and liver enzymes with significantly lower fasting blood glucose level than the control group.The total effective rates were comparable between the two groups.Conclusion JZQBR improves T2DM complicated with hyperlipidemia possibly by multi-target regulation of the inflammation-metabolism network.关键词
降脂祛斑方/2 型糖尿病/高脂血症/网络药理学Key words
Jiangzhi Quban recipe/type 2 diabetes mellitus/hyperlipidemia/network pharmacology引用本文复制引用
李钊泳,周凤华,孙晓敏,赵华杉,金瑶,何培坤,贾钰华..降脂祛斑方多成分协同调控炎症-代谢网络改善2型糖尿病合并高脂血症:网络药理学与临床验证[J].南方医科大学学报,2026,46(1):83-93,11.基金项目
国家自然科学基金(82174299,82574757) （82174299,82574757）
贾钰华省名中医传承工作室建设项目 Supported by National Natural Science Foundation of China(82174299,82574757). （82174299,82574757）
