福建师范大学学报（自然科学版）2026，Vol.42Issue(1)：48-56,9.DOI:10.12046/j.issn.1000-5277.2025100012
组氨酸三联体超家族蛋白的研究进展
Recent Advances in Research on Histidine Triad Superfamily Proteins
摘要
Abstract
The histidine triad(HIT)proteins are widely distributed across various organisms and constitute a superfamily of nucleotide hydrolases/transferases,characterized by the catalytic motif HxHxH.These proteins can be classified into three major branches:HINT,FHIT,and GALT.HIT superfamily proteins play crucial roles in DNA repair,signal transduction,and disease progression,and their aberrant expression or mutation is also associated with various diseases,such as cancer and neurodegenerative diseases.Therefore,a systematic comparison and analysis of the structural features and catalytic mechanisms of the HIT superfamily proteins is essential for under-standing their functional roles in different physiological processes.This knowledge may provide valu-able insights for the design of small-molecule drugs targeting these proteins and ultimately contribute to the early diagnosis and treatment of diseases such as cancer.关键词
组氨酸三联体家族/核苷酸水解酶/核苷酸转移酶/功能/机制Key words
histidine triad(HIT)proteins/nucleotide hydrolases/nucleotide transferases/mechanism/function分类
生物科学引用本文复制引用
张凯琼,欧阳松应,关洪鑫..组氨酸三联体超家族蛋白的研究进展[J].福建师范大学学报（自然科学版）,2026,42(1):48-56,9.基金项目
国家自然科学基金项目(32171265) （32171265）
