福建师范大学学报（自然科学版）2026，Vol.42Issue(1)：64-71,8.DOI:10.12046/j.issn.1000-5277.2025030034
表面增强拉曼光谱技术在生物传感及医学诊断中的应用与进展
Applications and Advances of Surface-Enhanced Raman Spectroscopy in Biosensing and Medical Diagnostics
摘要
Abstract
Surface-enhanced Raman spectroscopy(SERS)technology demonstrates significant advantages and considerable potential in applications such as biomolecular recognition,disease biomarker detection,and drug metabolism analysis.This review systematically elaborates on the application of SERS sensors in complex biomedical scenarios.It examines design strategies for high-performance SERS sensors tailored for complex biological media,including the design and properties of SERS substrates of various dimensions,as well as their application in the ultrasensitive detection of biomarkers.Furthermore,this review summarizes breakthroughs in SERS sensing strategies for practical clinical samples,explores feasible approaches to achieving higher specificity and biocom-patibility,and outlines future directions for the development of next-generation biomedical analysis technologies.关键词
表面增强拉曼光谱/SERS基底/生物传感器/医学诊断分析/生物分子识别/疾病标志物检测/药物代谢分析Key words
surface-enhanced Raman spectroscopy/SERS substrate/biosensor/medical diag-nostic analysis/biomolecular recognition/disease biomarker detection/drug metabolism analysis分类
化学化工引用本文复制引用
杨婧蕾,庄鑫,游瑞云,卢玉栋..表面增强拉曼光谱技术在生物传感及医学诊断中的应用与进展[J].福建师范大学学报（自然科学版）,2026,42(1):64-71,8.基金项目
"十四五"国家重点研发计划(2023YFC3906303) （2023YFC3906303）
福建省自然科学基金项目(2025J01626) （2025J01626）
