分析化学2025，Vol.53Issue(12)：1988-2000,13.DOI:10.19756/j.issn.0253-3820.251281
适配体生物传感器在毒品检测中的研究进展
Research Progress of Aptamer Biosensors in Detection of Illicit Drug
摘要
Abstract
Illicit drugs are a public hazard to human society.Developing rapid,sensitive and specific new methods for illicit drug detection is a key issue in the field of illicit drug control.Aptamers,as a type of single-stranded DNA or RNA molecules selected through the exponential enrichment ligand system evolution technology,are renowned as ″chemical antibodies″ due to their high affinity,high specificity and good stability.Aptamer biosensors,as an integration of biotechnology and sensing technology,provide a research approach for illicit drug detection that combines sensitivity,selectivity and real-time performance through the synergistic effect of high-specificity molecular recognition and multi-modal signal conversion.This article focuses on summarizing the recognition principles and detection methods of aptamer biosensors,providing a detailed review of the latest application progress of aptamer biosensors in various illicit drug detections,analyzing the challenges in aptamer screening,sensor construction and drug control practical applications,and looking forward to future development directions.This article is anticipested to provide reference and inspiration for the research and application of biosensors in illicit drug detection fields.关键词
适配体/生物传感器/毒品检测/评述Key words
Aptamer/Biosensors/Illicit drugs detection/Review引用本文复制引用
殷勤红,吕建华,陈俊秋,陈蕾,张硕玲,李唯,李云鹏,朱艳琴..适配体生物传感器在毒品检测中的研究进展[J].分析化学,2025,53(12):1988-2000,13.基金项目
国家自然科学基金项目(No.82260337)和国家级大学生创新创业训练计划项目(No.202411392001)资助. Supported by the National Natural Science Foundation of China(No.82260337)and the National College Students'Innovation and Entrepreneurship Training Program(No.202411392001). （No.82260337）
