口腔疾病防治2026，Vol.34Issue(1)：75-85,11.DOI:10.12016/j.issn.2096-1456.202550175
4D打印技术在骨组织工程中的研究进展
Research progress on 4D printing technology for bone tissue engineering
摘要
Abstract
The repair of bone defects is heavily influenced by the dynamic osteogenic microenvironment.Static scaf-folds constructed by traditional 3D printing technology cannot simulate the dynamic nature of the microenvironment dur-ing bone defect repair due to the fixed structure,uncontrollable release of active factors,and difficult regeneration of blood vessels,among other factors.Breaking through the limitations of these static scaffolds and realizing the intelligent and dynamic regulation of the osteogenic microenvironment is a key scientific issue in the field of bone tissue engineer-ing.4D printing technology combines the dynamic responsiveness of bone restoration materials with the concept of intel-ligent design to regulate the micro and macro structure of scaffolds.This technology provides a new method for bone tis-sue engineering by responding to endogenous and exogenous stimuli and creating a better osteogenic microenvironment through functionalized design,including drug delivery and antibacterial function.However,this technology currently suffers from challenges related to dynamic response material design,insufficient precision of printing technology,and mismatches between multi-stimulus response systems,metabolic rhythms of bone tissue,and functionalized composite scaffolds.Future research should focus on the development of smart response materials with excellent dynamic re-sponses and bioactivity,the creation of new printing technologies,and the design of personalized and precise bone re-pair solutions.The aim of this paper is to review the current research status of 4D printing for bone tissue engineering in terms of material types,response mechanisms,and applications to provide a theoretical basis for the development and clinical application of functional bone repair materials in the future.关键词
4D打印/骨缺损修复/动态响应能力/智能设计/支架材料/成骨微环境/功能化设计/个性化设计Key words
4D printing/bone defect repair/dynamic responsiveness/intelligent design/scaffold materials/osteogenic microenvironment/functional design/personalized design分类
医药卫生引用本文复制引用
王培煜,石雅茹,孙一帆,徐晓薇..4D打印技术在骨组织工程中的研究进展[J].口腔疾病防治,2026,34(1):75-85,11.基金项目
国家自然科学基金面上项目(82470957) （82470957）
吉林大学研究生创新基金资助项目(2024CX254) This study was supported by the grants from National Natural Science Foundation of China(No.82470957)and Gradu-ate Innovation Fund of Jilin University(No.2024CX254). （2024CX254）
