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Persistent accumulation of therapy-induced senescent cells:an obstacle to long-term cancer treatment efficacy

Jingjing Luo Tongxu Sun Zhenghui Liu Yangfan Liu Junjiang Liu Shimeng Wang Xueke Shi Hongmei Zhou

国际口腔科学杂志（英文版）2025，Vol.17Issue(6)：735-755,21.

国际口腔科学杂志（英文版）2025，Vol.17Issue(6)：735-755,21.DOI:10.1038/s41368-025-00380-w

Persistent accumulation of therapy-induced senescent cells:an obstacle to long-term cancer treatment efficacy

Jingjing Luo ¹Tongxu Sun ¹Zhenghui Liu ²Yangfan Liu ¹Junjiang Liu ¹Shimeng Wang ³Xueke Shi ¹Hongmei Zhou¹

作者信息

1. State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Frontier Innovation Center for Dental Medicine Plus&West China Hospital of Stomatology,Sichuan University,Chengdu,China
2. Department of Medicine,University of Colorado,Anschutz Medical Campus,Aurora,CO,USA
3. State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Frontier Innovation Center for Dental Medicine Plus&West China Hospital of Stomatology,Sichuan University,Chengdu,China||Department of Pathology and Laboratory Medicine,School of Medicine,University of California,Davis,Sacramento,CA,USA
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Jingjing Luo,Tongxu Sun,Zhenghui Liu,Yangfan Liu,Junjiang Liu,Shimeng Wang,Xueke Shi,Hongmei Zhou..Persistent accumulation of therapy-induced senescent cells:an obstacle to long-term cancer treatment efficacy[J].国际口腔科学杂志（英文版）,2025,17(6):735-755,21.

基金项目

This work was supported by Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2023ZD0503000),National Natural Science Foundation of China(No.82301095,82301094),Sichuan Science and Technology Program(No.2025ZNSFSC0548,2024YFFK0373),and the Research Funding from West China Hospital of Stomatology,Sichuan University(No.RD-03-202410).We'd like to thank Bachelor Yuanyi Xiang and Master Deyang Wu for their assistance in Figs.1 and 3.Additionally,we would like to express our great gratitude to the professional language editing service from Elsevier Author Services(EAS)and American Journal Experts(AJE). （No.2023ZD0503000）

国际口腔科学杂志（英文版）

ISSN：1674-2818

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