国际口腔医学杂志2026，Vol.53Issue(1)：36-42,7.DOI:10.7518/gjkq.2026002
牙髓间充质干细胞与巨噬细胞交互作用的研究进展
Progress in the study of cellular interactions between dental pulp mesenchymal stem cells and macrophages
摘要
Abstract
Dental pulp mesenchymal stem cells(or dental pulp stem cells)are mesenchymal stem cells derived from dental pulp tissues,possessing notable capacities for immunomodulation and tissue regeneration.Macrophages,as key im-mune effector cells,are prevalent in inflammatory microenvironments and exhibit phenotypic plasticity through polariza-tion into distinct functional subsets.Hence,understanding the bidirectional interactions between dental pulp mesenchymal stem cells and macrophages is essential for advancing the therapeutic application of dental pulp mesenchymal stem cells in inflammation-related diseases.This review explores the mechanisms by which dental pulp mesenchymal stem cells in-fluence macrophage polarization,migration,and differentiation and how macrophages of various phenotypes influence the proliferation and differentiation of dental pulp mesenchymal stem cells.关键词
牙髓间充质干细胞/巨噬细胞/细胞相互作用/免疫调节/细胞分化Key words
dental pulp mesenchymal stem cell/macrophage/cellular interaction/immunoregulation/cellular dif-ferentiation分类
生物科学引用本文复制引用
徐泽楷,吴文治,陈卓..牙髓间充质干细胞与巨噬细胞交互作用的研究进展[J].国际口腔医学杂志,2026,53(1):36-42,7.基金项目
National Natural Science Foundation of China(82270964) 国家自然科学基金(82270964) （82270964）
