国际口腔医学杂志2026，Vol.53Issue(1)：51-58,8.DOI:10.7518/gjkq.2026206
局部应用环孢素治疗口腔扁平苔藓的有效性和安全性的Meta分析
Meta-analysis of the efficacy and safety of topical cyclosporine in the treatment of oral lichen planus
摘要
Abstract
Objective This study aimed to evaluate the efficacy and safety of topical cyclosporine in the treatment of oral lichen planus(OLP)and to provide reference for clinicians.Methods Databases,such as Pubmed,Embase,The Co-chrane Library,Web of Science,CNKI,WanFang Data,and VIP,were searched.The System for Information on Grey Li-terature in Europe(SIGLE)and ClinicalTrials websites were searched online to collect randomized controlled trials(RCTs)of cyclosporine for OLP from the establishment of the database to March 25,2023.Two reviewers independently evalua-ted the study quality and extracted data,and meta-analysis was performed using RevMan(version 5.4)and STATA(ver-sion 14.0)software.Results A total of seven RCT studies on cyclosporine in the treatment of OLP were included,in-cluding 317 patients.Among them,six compared cyclo-sporine with corticosteroid,and one compared cyclospo-rine with placebo.Meta-analysis results showed no sta-tistically significant difference in clinical effectiveness between the cyclosporine and corticosteroid groups[risk ratio(RR)=0.87,95%confidence interval(CI):0.67-1.14,P=0.32].After 4 weeks of treatment,no statistically significant difference was observed in the improvement of pain scores between the cyclosporine and corticosteroid groups(standardized mean difference=-0.23,95%CI:-0.54-0.07,P=0.13).No statistically significant difference was found in the incidence of adverse reactions between the cyclosporine and corticosteroid groups(RR=0.71,95%CI:0.18-2.79,P=0.62).Conclusion Current evidence shows that cyclosporine has no advantage over corticosteroid in terms of clinical efficacy,improvement in pain scores,and safety.More high-quality studies are required to verify the above conclusion due to limitations in the quantity and quality of included studies.关键词
口腔扁平苔藓/环孢素/系统评价/Meta分析Key words
oral lichen planus/cyclosporine/systematic review/Meta-analysis分类
医药卫生引用本文复制引用
汪星,李莎,郭锦材..局部应用环孢素治疗口腔扁平苔藓的有效性和安全性的Meta分析[J].国际口腔医学杂志,2026,53(1):51-58,8.基金项目
Nature Science Foundation of Hunan Province(2024JJ9532) （2024JJ9532）
Hunan University of Chinese Medicine Re-search Fund Project(2022XYLH134) 湖南省自然科学基金(2024JJ9532) （2022XYLH134）
湖南中医药大学校院联合基金项目(2022XYLH134) （2022XYLH134）
