国际口腔医学杂志2026，Vol.53Issue(1)：67-75,9.DOI:10.7518/gjkq.2026208
程序性细胞死亡配体1与头颈癌风险的孟德尔随机化研究
A Mendelian randomization study of programmed cell death ligand 1 with the risk of head and neck cancer
摘要
Abstract
Objective This study aimed to assess the causal relationship between programmed cell death ligand 1(PD-L1)and the risk of head and neck cancer.Methods Mendelian randomization(MR)was performed using large-scale ge-netic data to evaluate the causal relationship between PD-L1 and the risk of different types of head and neck cancers via inverse variance weighted(IVW),Mendelian randomization-Egger(MR-Egger),simple mode,and weighted median.Ad-ditionally,MR-Egger and Mendelian randomization pleiotropy residual sum and outlier(MR-PRESSO)were used to ana-lyze horizontal pleiotropy,Cochran's Q test was performed to examine heterogeneity,and leave-one-out experiment was conducted to measure sensitivity.Results The genetic prediction results revealed a causal relationship between PD-L1 and head and neck squamous cell carcinoma(HNSCC)(OR=1.000 3,95%CI:1.000 0-1.000 6,P=0.049)and between PD-L1 and oral cavity and oropharyngeal cancer(OC&PC)(OR=1.000 3,95%CI:1.000 1-1.000 6,P=0.018).Conclu-sion PD-L1 may be a risk factor for the development of HNSCC and OC&PC.关键词
孟德尔随机化/程序性死亡配体1/头颈癌/风险Key words
Mendelian randomization/programmed cell death ligand 1/head and neck cancer/risk分类
医药卫生引用本文复制引用
尚宏悦,刘铁军,姚曼曼,路月亭,董博,宋炜晶,张纪傲..程序性细胞死亡配体1与头颈癌风险的孟德尔随机化研究[J].国际口腔医学杂志,2026,53(1):67-75,9.基金项目
Central Government Guides Local Science And Technology Development Fund Projects(246Z7762G) 中央引导地方科技发展资金项目(246Z7762G) （246Z7762G）
