Pharmacological inhibition of RAS pathway alleviates spine deformity in a mouse model of neurofibromatosis type 1
Pharmacological inhibition of RAS pathway alleviates spine deformity in a mouse model of neurofibromatosis type 1
摘要
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Franceska Kovaci,Cassandre Goachet,Simon Perrin,Lotfi Slimani,Fanny Coulpier,Françoise Tilotta,Piotr Topilko,Céline Colnot..Pharmacological inhibition of RAS pathway alleviates spine deformity in a mouse model of neurofibromatosis type 1[J].骨研究（英文版）,2025,13(6):1463-1474,12.基金项目
This work was supported by:Association Neurofibromatoses et Recklinghausen(C.C),Agence Nationale de la Recherche-18-CE14-0033(C.C.,P.T.),Agence Nationale de la Recherche-21-CE18-007-01(C.C.,P.T.),US Department of the Army NF220019(C.C.).F.Kovaci and C.Goachet were supported by a PhD fellowship from the University Paris-Est Créteil and the Fondation pour la Recherche Médicale(FRM)(FDT202304016600 to FK and ECO202306017399 to CG).We thank C.Chaussain for her support and K.Henri and B.Castel from the Small Animal Platform,Life Imaging Facility of Paris Cité University(EA2496,Paris Cité),Montrouge.We thank all the IMRB animal facility staff,the cytometry platform,and S.Protic and S.Lakhlifi for their technical assistance.We thank Revolution Medicines,Inc.,Redwood City,CA.,for providing RMC-4550. （C.C）
