广州中医药大学学报2026，Vol.43Issue(1)：8-16,9.DOI:10.13359/j.cnki.gzxbtcm.2026.01.002
新疆地区部分活动性肺结核患者KIR亚型及中医证型分布规律研究
Study on the Distribution Patterns of KIR Subtypes and TCM Syndrome Types in Partial Patients with Active Pulmonary Tuberculosis in Xinjiang Region
摘要
Abstract
Objective To investigate the relationship between traditional Chinese medicine(TCM)syndrome types and the distribution of killer-cell immunoglobulin-like receptor(KIR)subtypes in partial patients with active pulmonary tuberculosis(PTB)in the Xinjiang region,and to understand the clinical characteristics of these patients,in order to provide a basis for clinical auxiliary diagnosis of tuberculosis.Methods(1)A total of 338 patients with active PTB treated in the Department of Respiratory and Critical Care Medicine at the Eighth Affiliated Hospital of Xinjiang Medical University from January to October 2021 were enrolled,including 230 newly-treated cases and 108 retreated cases.Descriptive analysis was used to analyze general data,clinical manifestations,and comorbidities.(2)Whole blood samples were collected from 230 active PTB patients(130 newly-treated cases,100 retreated cases)from the same department and period,and 108 healthy individuals from the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University and Urumqi Youai Hospital Health Examination Center.Genomic DNA was extracted using a whole blood DNA extraction kit.Four KIR subtypes(KIR2DL3,KIR2DS1,KIR2DS3,and KIR3DS1)were detected.The distribution of KIR subtypes in active PTB patients was compared with that in healthy controls to explore its pattern.TCM syndrome differentiation was performed for newly-treated and retreated patients to explore the distribution characteristics of TCM syndrome types in active PTB in Xinjiang and to investigate the association between KIR subtypes and TCM syndrome types.Results(1)Among the 338 active PTB patients,there were 230 newly-treated cases and 108 retreated cases,with a mean age of(51.68±19.93)years.The top six clinical manifestations in newly-treated cases were cough,expectoration,poor appetite,poor sleep,weakness,and chest tightness with shortness of breath;in retreated cases,they were cough,expectoration,poor appetite,chest tightness with shortness of breath,poor sleep,and weakness.The frequencies of cough,expectoration,and shortness of breath after activity were higher in retreated cases than in newly-treated cases(P＜0.05 or P＜0.01).The top five comorbidities in newly-treated cases were type 2 diabetes,hypertension,coronary heart disease,tuberculous meningitis,and chronic bronchitis;in retreated cases,they were hypertension,type 2 diabetes,coronary heart disease,chronic bronchitis,and gallstones with chronic cholecystitis.The proportion of newly-treated cases complicated with tuberculous meningitis was relatively high(P＜0.05),while the proportion of retreated cases complicated with chronic obstructive pulmonary disease was relatively high(P＜0.05).(2)The distribution of TCM syndrome types in newly-treated/retreated active PTB patients was:qi and yin deficiency syndrome>yin and yang deficiency syndrome>yin deficiency resulting in vigorous fire syndrome>lung yin depletion syndrome.The inhibitory subtype KIR2DL3 and the activating subtype KIR2DS1 were widely present in both active PTB patients and healthy controls.Among retreated cases,the distribution proportion of KIR2DS3 was relatively high.Active PTB patients with qi and yin deficiency syndrome mainly expressed KIR2DL3 and KIR2DS1 subtypes.KIR2DS3 might be a specific marker for lung yin depletion syndrome in active PTB patients[OR(95%CI)=2.754(1.019,7.448),P=0.046].Conclusion In partial patients with active PTB in the Xinjiang region,qi and yin deficiency syndrome is the predominant TCM syndrome type.Clinical manifestations differ between newly-treated and retreated cases,with complex comorbidities.KIR2DS3 may be a specific marker for lung yin depletion syndrome in active PTB patients.The expression of KIR2DL3 and KIR2DS1 subtypes may be closely related to qi and yin deficiency syndrome in active PTB.关键词
活动性肺结核/中医证型分布/气阴两虚证/肺阴亏虚证/杀伤性免疫球蛋白样受体/抑制性亚型/活化性亚型/新疆地区Key words
active pulmonary tuberculosis/TCM syndrome type distribution/qi and yin deficiency syndrome/lung yin depletion syndrome/killer cell immunoglobulin-like receptor/inhibitory subtype/activating subtype/Xinjiang region分类
医药卫生引用本文复制引用
丁萌譞,吴斯琦,孙宾莲,王泉,舒占钧..新疆地区部分活动性肺结核患者KIR亚型及中医证型分布规律研究[J].广州中医药大学学报,2026,43(1):8-16,9.基金项目
省部共建中亚高发病成因与防治重点实验室开放课题项目(编号:SKL-HIDCA-2019-ZY4) （编号:SKL-HIDCA-2019-ZY4）
