广州中医药大学学报2026，Vol.43Issue(1)：35-42,8.DOI:10.13359/j.cnki.gzxbtcm.2026.01.006
温肾消癥汤联合地诺孕素对子宫内膜异位症患者子宫超声指标及血清AOPP水平的影响
Effects of Wenshen Xiaozheng Decoction Combined with Dienogest on Uterine Ultrasound Parameters and Serum AOPP Levels in Patients with Endometriosis
摘要
Abstract
Objective To investigate the therapeutic effect of Wenshen Xiaozheng Decoction combined with dienogest on endometriosis(EMT)and to observe its impact on uterine ultrasound parameters and serum advanced oxidation protein products(AOPP)levels.Methods Using propensity score matching and a prospective design,525 EMT patients with kidney deficiency and blood stasis syndrome treated in the Gynecology Department of Gaoling District Traditional Chinese Medicine Hospital from March 2020 to March 2023 were enrolled,including 321 receiving dienogest and 204 receiving additional Wenshen Xiaozheng Decoction.After 1∶1 nearest neighbor matching,304 patients were successfully matched and then were divided into a western medicine group(n=152)and an integrated Chinese-western medicine group(n=152).The western medicine group received conventional dienogest,while the integrated group received additional Wenshen Xiaozheng Decoction.Both groups were treated for 6 months.Changes in uterine ultrasound parameters,traditional Chinese medicine(TCM)syndrome scores,dysmenorrhea conditions,sex hormone levels,and oxidative stress markers were observed before and after treatment.Clinical efficacy and safety were evaluated.Results(1)Regarding efficacy,after 6 months,the total effective rate was 93.42%(142/152)in the integrated group versus 78.29%(119/152)in the western medicine group.The intergroup comparison(by chi-square test)showed that the integrated group showed significantly superior efficacy(P＜0.01).(2)Regarding outcome indicators,after treatment,cyst diameter decreased(P＜0.05)and dysmenorrhea duration shortened(P＜0.05)in both groups versus before treatment;TCM syndrome scores and dysmenorrhea VAS scores decreased(P＜0.05)in both groups,with significantly greater improvements in the integrated group(P＜0.01).(3)Regarding sex hormones,serum FSH,E2,and LH levels decreased in both groups after treatment(P＜0.05),with significantly greater reductions in the integrated group(P＜0.01).(4)Regarding oxidative stress,serum AOPP levels decreased(P＜0.05)and superoxide dismuntase(SOD)levels increased(P＜0.05)in both groups after treatment,with significantly greater changes in the integrated group(P＜0.01).(5)Regarding safety,the total adverse reaction incidence was 13.16%(20/152)in the integrated group and 9.87%(15/152)in the western medicine group,with no statistically significant difference(P＞0.05).Conclusion For EMT patients with kidney deficiency and blood stasis syndrome,Wenshen Xiaozheng Decoction combined with dienogest demonstrates definite clinical efficacy,effectively improving ovarian function,reducing oxidative damage,alleviating dysmenorrhea,regulating sex hormone levels,and reducing cyst size,with superior outcomes to dienogest alone and a comparable safety profile.关键词
子宫内膜异位症/肾虚血瘀型/地诺孕素/温肾消癥汤/晚期蛋白氧化产物/性激素/卵巢功能/氧化应激Key words
endometriosis/kidney deficiency and blood stasis syndrome/dienogest/Wenshen Xiaozheng Decoction/advanced oxidation protein products/sex hormones/ovarian function/oxidative stress分类
医药卫生引用本文复制引用
王萍,张春霞..温肾消癥汤联合地诺孕素对子宫内膜异位症患者子宫超声指标及血清AOPP水平的影响[J].广州中医药大学学报,2026,43(1):35-42,8.基金项目
陕西省重点研发计划项目(编号:2022-YBSF-137) （编号:2022-YBSF-137）
