广州中医药大学学报2026，Vol.43Issue(1)：56-62,7.DOI:10.13359/j.cnki.gzxbtcm.2026.01.009
基于宫颈Bishop评分联合胎儿纤维连接蛋白检测探讨保产无忧散诱导宫颈成熟的临床疗效
Clinical Research on the Induction of Cervical Maturity by Baochan Wuyou San Based on Cervical Bishop Score Combined with Fetal Fibronectin Detection
摘要
Abstract
Objective To evaluate the clinical efficacy of Baochan Wuyou San in promoting cervical ripening based on cervical Bishop score combined with fetal fibronectin(fFN)detection.Methods A total of 115 full-term pregnant women with indications for labor induction,admitted to the Department of Obstetrics at Shenzhen Traditional Chinese Medicine Hospital between June 2023 and June 2024,were enrolled and randomly divided into three groups using a random number table:35 cases in the western medicine group,and 40 cases each in the traditional Chinese medicine(TCM)group and the integrated Chinese-western medicine group.The western medicine group received induction via cervical dilation balloon placement and/or intravenous infusion of oxytocin.The TCM group received oral administration of Baochan Wuyou San alone for induction.The integrated group received oral use of Baochan Wuyou San followed by cervical dilation balloon placement and/or intravenous of infusion oxytocin.Cervical maturity was assessed using Bishop score combined with fFN detection.Changes in cervical maturity before and after intervention were analyzed,and comparisons were made among the three groups regarding cervical maturity,delivery mode,birth canal injury,durations of various stages of labor(first,second,third,and overall stages),and 24-hour postpartum blood loss.Results(1)Regarding delivery mode,the vaginal delivery rates were 62.86%(22/35)in the western medicine group,55.00%(22/40)in the TCM group,and 82.50%(33/40)in the integrated group.The vaginal delivery rate in the integrated group was significantly higher than that in the TCM group(P＜0.05),and there were no statistically significant differences between the TCM group and western medicine group(P＞0.05).There were no statistically significant differences among the three groups in terms of maternal type(primipara,multipara)and birth canal laceration(P＞0.05).In terms of gestational weeks,labor stages,and blood loss,the durations of the first stage and total labor in the integrated group were significantly shorter than those in the TCM and western medicine groups(P＜0.05).However,no significant differences were found among the three groups in gestational weeks,durations of the second and third stages of labor,or 24-hour postpartum blood loss(P＞0.05).(2)Regarding cervical maturity,the proportion of cases with Bishop scores＜6 and negative fFN was decreased after intervention in all three groups,while the proportion with Bishop scores≥6 and positive fFN was increased,with statistically significant differences(P＜0.01).After intervention,the integrated group showed a significantly higher proportion of cases with Bishop scores≥6 and positive fFN was compared to the TCM and western medicine groups(P＜0.05).Conclusion The combination of Baochan Wuyou San with cervical dilation balloon and/or intravenous infusion of oxytocin may be more effective in promoting cervical ripening,increasing the rate of vaginal delivery,and reducing the duration of the first and total stages of labor.This study provides valuable insights for optimizing clinical delivery strategies.关键词
胎儿纤连蛋白/宫颈Bishop评分/保产无忧散/宫颈成熟/顺产率/临床研究Key words
fetal fibronectin(fFN)/cervical Bishop score/Baochan Wuyou San/cervical ripening/vaginal delivery rate/clinical study分类
医药卫生引用本文复制引用
骆世存,罗盈,黄雅,吴惠君,成靖..基于宫颈Bishop评分联合胎儿纤维连接蛋白检测探讨保产无忧散诱导宫颈成熟的临床疗效[J].广州中医药大学学报,2026,43(1):56-62,7.基金项目
广东省中医药局科研项目(编号:20231301) （编号:20231301）
深圳市中医院"3030"计划中医临床研究项目(编号:2022042911) （编号:2022042911）
