基础医学与临床2026，Vol.46Issue(1)：16-21,6.DOI:10.16352/j.issn.1001-6325.2026.01.0016
血清galectin-10、STAT3、CCL19水平与慢性湿疹患者疾病严重程度相关
Level of serum galectin-10,STAT3 and CCL19 is correlated with disease severity in patients with chronic eczema
摘要
Abstract
Objective To investigate potential correlation of serum galectin-10(Gal-10),signal transducer,activa-tor of transcription 3(STAT3)and C-C chemokine ligand 19(CCL19)with severity of chronic eczema.Methods From October 2022 to October 2024,104 patients admitted to the 7th People's Hospital of Zhengzhou with chronic eczema were reviewed.Based on implicated area of eczema and severity index(EASI)score,they were assigned into mild group(EASI score≤10 points,43 cases),moderate group(10 points＜EASI score≤19 points,36 ca-ses),and severe group(EASI score≥20 points,25 cases).Meantime,60 healthy individuals from routine physi-cal check were selected as control group.ELISA was used to detect serum Gal-10,STAT3,and CCL19.Spearman correlation was performed to analyze the correlation between serum Gal-10,STAT3,CCL19 levels with EASI score in patients.Logistic regression was performed to analyze the factors affecting the condition of patients.Receiver operat-ing characteristic(ROC)curves were used to evaluate the diagnostic value of serum Gal-10,STAT3,and CCL19 for the severity of chronic eczema.Results The case group had manifestly higher serum Gal-10,STAT3 and CCL19 than control group(P＜0.05).The moderate and severe groups had conspicuous higher EASI scores and serum Gal-10,STAT3 and CCL19 than mild group(P＜0.05);And with severe group being conspicuously higher than moder-ate group(P＜0.05).Serum Gal-10,STAT3,CCL19 in patients with chronic eczema were positively correlated with EASI score(r=0.606,0.417,0.507,P＜0.05).The elevated EASI score,serum Gal-10,STAT3 and CCL19 were all believed to be risk factors to aggravate chronic eczema(P＜0.05).The area under the curve(AUC)of serum Gal-10,STAT3,CCL19 alone and in combination for diagnosing the severity of chronic eczema was 0.827,0.811,0.803,and 0.914,respectively.The combined diagnostic efficacy was superior to the individual detection of the three(Zthree combination-Gal-10=2.703,Zthree combination-STAT3=2.251,Zthree combination-CCL19=2.795,all P＜0.05).Conclusions The serum level of Gal-10,STAT3 and CCL19 in patients with chronic eczema are elevated and correlated with se-verity of the disease.The combined detection of the three combined index factor may support clinical evaluation of the severity of chronic eczema.关键词
半乳糖凝集素-10/信号传导及转录激活因子3/趋化因子配体19/慢性湿疹/疾病严重程度Key words
galectin-10/signal transducer and activator of transcription 3/C-C chemokine ligand 19/chronic eczema/severity of disease分类
医药卫生引用本文复制引用
孟小卉,姜诗谣,杨怡..血清galectin-10、STAT3、CCL19水平与慢性湿疹患者疾病严重程度相关[J].基础医学与临床,2026,46(1):16-21,6.基金项目
河南省医学科技攻关计划(LHGJ2022001) （LHGJ2022001）
