基础医学与临床2026，Vol.46Issue(1)：129-133,5.DOI:10.16352/j.issn.1001-6325.2026.01.0129
肠道菌群紊乱与糖尿病心肌病
Gut microbiota dysbiosis and diabetic cardiomyopathy
摘要
Abstract
Dysregulation of gut microbiota and its metabolites contributes to diabetic cardiomyopathy(DCM)prima-rily through inflammation,oxidative stress,energy metabolism disturbances,insulin resistance,apoptosis and auto-phagy.Gut microbiota dysbiosis disrupts intestinal barrier function,triggering inflammation and oxidative stress,which exacerbate myocardial inflammation and damage.Additionally,gut microbiota modulates bile acid metabo-lism,influencing the activation of Takeda G protein-coupled receptor 5(TGR5),thereby affecting glucose and lipid metabolism as well as cardiac function.Metabolites such as trimethylamine N-oxide(TMAO)may activate inflam-matory pathways and impair insulin signaling,reducing insulin sensitivity and exacerbating glucose metabolism dis-orders,further aggravating DCM.Targeting the gut microbiota composition and restoring the homeostasis of its me-tabolites may be potential strategy for the prevention and treatment of DCM.关键词
糖尿病/心肌病变/肠道菌群/代谢紊乱/胆汁酸Key words
diabetes/cardiomyopathy/gut microbiota/metabolic disorder/bile acids分类
医药卫生引用本文复制引用
孙清怡,陈果,符晓,孙海建,陆清波..肠道菌群紊乱与糖尿病心肌病[J].基础医学与临床,2026,46(1):129-133,5.基金项目
国家自然科学基金(82370364,82170424) （82370364,82170424）
