健康研究2025，Vol.45Issue(6)：613-620,8.DOI:10.19890/j.cnki.issn1674-6449.2025.06.003
减重疗法的研究进展与展望:从生活方式干预到新型药物
Research progress and future directions in weight loss therapies:from lifestyle interventions to novel pharmacological agents
摘要
Abstract
Obesity has evolved into a global public health crisis,necessitating multimodal and individualized comprehensive management.This review systematically summarizes the mechanisms,efficacy,and safety profiles of mainstream and emerging weight loss therapies,aiming to inform clinical practice.Lifestyle intervention remains the cornerstone of all treatments,with regimens such as the Mediterranean diet and intermittent fasting garnering significant attention due to their unique mechanisms.The field of pharmacotherapy has witnessed landmark breakthroughs,exemplified by novel agents like glucagon-like peptide-1(GLP-1)receptor agonists.The weight loss efficacy of these agents is now comparable to metabolic surgery and is associated with cardiovascular benefits independent of weight reduction.Endoscopic bariatric therapies serve as minimally invasive options,effectively bridging the gap between pharmacotherapy and surgery.For severe obesity,metabolic surgery remains the most effective and durable intervention.Looking ahead,weight management strategies will increasingly focus on etiology-based,personalized comprehensive management,with early intervention and long-term weight maintenance,underpinned by the principle of"preventive treatment,"emerging as central future directions.关键词
肥胖/减重疗法/生活方式干预/GLP-1受体激动剂/代谢与减重手术Key words
obesity/weight loss therapy/lifestyle intervention/GLP-1 receptor agonists/metabolic and bariatric surgery分类
医药卫生引用本文复制引用
孙蕾民,刘艺鸣..减重疗法的研究进展与展望:从生活方式干预到新型药物[J].健康研究,2025,45(6):613-620,8.基金项目
国家自然科学基金青年项目(82203828) （82203828）
