健康研究2025，Vol.45Issue(6)：629-633,5.DOI:10.19890/j.cnki.issn1674-6449.2025.06.006
体重指数和血清β-hCG与多囊卵巢综合征体外受精-胚胎移植患者妊娠结局的关系
Relationship between body mass index and serum β-hCG and pregnancy outcomes in patients with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer
摘要
Abstract
Objective To explore the relationship between serum β-human chorionic gonadotropin(β-hCG)levels,body mass index(BMI),and pregnancy outcomes in patients with polycystic ovary syndrome(PCOS)undergoing in vitro fertilization-embryo transfer(IVF-ET),and to provide evidence for improving clinical outcomes through weight management.Methods Clinical data from 202 PCOS patients undergoing IVF-ET were analyzed.Based on serum β-hCG levels on day 12 after D3 embryo transfer or day 10 after blastocyst transfer,patients were divided into a low β-hCG group(<50 IU/L)and a high β-hCG group(≥50 IU/L).Embryo development and pregnancy outcomes were compared between these two groups.According to BMI,patients were further categorized into a normal-weight group(<24 kg/m2)and an overweight/obese group(≥24 kg/m2),and pregnancy outcomes were compared between these BMI categories.Spearman correlation analysis was used to examine the relationships between serum β-hCG,BMI,and pregnancy outcomes.Results The proportions of biochemical pregnancy and early spontaneous abortion in the high β-hCG group(8.95%and 12.69%,respectively)were significantly lower than those in the low β-hCG group(27.94%and 35.29%,respectively),with a statistically significant difference in abnormal pregnancy outcomes between the two groups(χ2=34.020,P<0.001).The incidence of abnormal pregnancy outcomes in the normal-weight group(27.19%)was significantly lower than that in the overweight/obese group(46.59%)(χ2=8.776,P=0.012).Pregnancy outcomes in PCOS patients showed a positive correlation with serum β-hCG levels(r=0.384)and a negative correlation with BMI(r=-0.162),both P<0.05.Conclusions Serum β-hCG levels and BMI are significantly correlated with pregnancy outcomes in PCOS patients after IVF-ET.Pre-transfer weight management and postoperative β-hCG monitoring may help improve pregnancy outcomes in this population.关键词
多囊卵巢综合征/体外受精-胚胎移植/体重指数/妊娠结局/体重管理Key words
polycystic ovary syndrome/in vitro fertilization-embryo transfer/body mass index/pregnancy outcomes/weight management分类
医药卫生引用本文复制引用
高辉,师帅,余柯达,何健英..体重指数和血清β-hCG与多囊卵巢综合征体外受精-胚胎移植患者妊娠结局的关系[J].健康研究,2025,45(6):629-633,5.基金项目
金华市科学技术研究计划重点项目(2023-3-132 （）
2023-3-138) （）
