健康研究2025，Vol.45Issue(6)：640-644,673,6.DOI:10.19890/j.cnki.issn1674-6449.2025.06.008
SIRT6在糖脂代谢中的调控作用
The regulatory role of SIRT6 in glucose and lipid metabolism
摘要
Abstract
Silent information regulator 6(SIRT6)is widely expressed in various tissues and organs,with relatively higher levels observed in the thymus,skeletal muscle,and brain.SIRT6 improves tissue insulin sensitivity,mitigates systemic insulin resistance,and contributes to glucose homeostasis.In lipid metabolism,SIRT6 promotes fatty acid oxidation in the liver and suppresses hepatic steatosis.In adipose tissue,it enhances thermogenesis and lipolysis,thereby reducing lipid accumulation.In skeletal muscle,SIRT6 facilitates fatty acid oxidation via AMPK activation.Overall,SIRT6 plays a crucial role in maintaining metabolic homeostasis and represents a promising therapeutic target for metabolic disorders such as obesity and diabetes.This article reviews the regulatory effects of SIRT6 on glucose and lipid metabolism across multiple tissues,aiming to provide a reference for future experimental and clinical research.关键词
沉默信息调节因子6/糖代谢/脂代谢/肥胖Key words
SIRT6/glucose metabolism/lipid metabolism/obesity分类
医药卫生引用本文复制引用
程瑞,叶家驰,刘秀娟,马驰,王慕芸..SIRT6在糖脂代谢中的调控作用[J].健康研究,2025,45(6):640-644,673,6.基金项目
国家自然科学基金(31900844) （31900844）
江苏省高校自然科学基金(17KJB180008) （17KJB180008）
南京体育学院大学生创新创业训练计划(202410330061Y （）
202410330031Y) （）
