解剖学杂志2025，Vol.48Issue(6)：527-531,544,6.DOI:10.3969/j.issn.1001-1633.2025.06.014
骨内淋巴管在骨折愈合与骨关节疾病中作用的研究进展
Research progress on role of intraosseous lymphatic vessels in fracture healing and bone and joint diseases
摘要
Abstract
The traditional view holds that bone tissue lacked lymphatic vessels,but recent studies utilizing advanced imaging techniques have confirmed the presence of functional lymphatics in bone,joints,and intervertebral discs.The lymphatic system plays a crucial role in bone homeostasis and repair by clearing metabolic waste and coordinating the immune microenvironment.Pathological inflammation can remodel lymphatic function,and targeting lymphatics(e.g.,modulating VEGF-C signaling)has shown potential to promote bone regeneration in animal models.Such findings have overturned traditional understanding,providing novel perspectives for understanding bone repair mechanisms and developing new therapies for bone and joint disorders.关键词
淋巴管/淋巴内皮细胞/骨折/骨性关节炎/类风湿性关节炎Key words
lymphatic vessel/lymphatic endothelial cell/fracture healing/osteoarthritis/rheumatoid arthritis分类
医药卫生引用本文复制引用
李瑞环,代冰洋,张元涛,陈洪江,黄钟炼,鲍铭贵,梁栩,胡军,许建坤..骨内淋巴管在骨折愈合与骨关节疾病中作用的研究进展[J].解剖学杂志,2025,48(6):527-531,544,6.基金项目
国家自然科学基金面上项目(32171332) （32171332）
国家自然科学基金青年项目(82202700) （82202700）
广东省自然科学基金面上项目(2024A1515012523 （）
2021A1515011204 （）
2021A1515011285) （）
汕头市科技计划项目(2020ST013) （2020ST013）
