解剖学杂志2025，Vol.48Issue(6)：532-535,4.DOI:10.3969/j.issn.1001-1633.2025.06.015
核受体共激活因子4调控铁死亡在椎间盘退变中的研究进展
Research progress on the role of nuclear receptor coactivator 4 in regulating ferroptosis in intervertebral disc degeneration
朱祥辉 1何天 1白登彦 2海向军 1张海军2
作者信息
- 1. 西北民族大学医学部解剖学教研室,兰州 730030
- 2. 西北民族大学附属甘肃省第二人民医院骨科,兰州 730099
- 折叠
摘要
Abstract
Nuclear receptor coactivator 4(NCOA4),a key protein in the regulation of intracellular iron homeostasis,has garnered increasing attention for its role in mediating ferroptosis during intervertebral disc degeneration(IVDD).IVDD is a degenerative condition characterized by nucleus pulposus cell senescence and degradation of the extracellular matrix.This article systematically reviews the molecular mechanisms by which NCOA4 triggers ferroptosis via the ferritinophagy pathway and focuses on the potential roles of NCOA4-associated signaling pathways in regulating iron metabolism dysregulation,oxidative stress,and nucleus pulposus cell apoptosis within the IVDD process.The aim of this review is to provide new insights for targeted therapies of IVDD.关键词
核受体共激活因子4/铁死亡/椎间盘退变Key words
nuclear receptor coactivator 4/ferroptosis/intervertebral disc degeneration分类
医药卫生引用本文复制引用
朱祥辉,何天,白登彦,海向军,张海军..核受体共激活因子4调控铁死亡在椎间盘退变中的研究进展[J].解剖学杂志,2025,48(6):532-535,4.
