实用临床医药杂志2025，Vol.29Issue(23)：16-21,6.DOI:10.7619/jcmp.20255701
抗核抗体、抗双链DNA抗体及单核细胞趋化蛋白-1与系统性红斑狼疮肾损伤的关系
Association of antinuclear antibody,anti-double-stranded DNA antibody,and monocyte chemoattractant protein-1 with renal injury in systemic lupus erythematosus
摘要
Abstract
Objective To investigate the associations between serum levels of antinuclear anti-body(ANA),anti-double-stranded DNA antibody(anti-dsDNA),and monocyte chemoattractant pro-tein-1(MCP-1)and renal injury in patients with systemic lupus erythematosus(SLE).Methods A case-control study was conducted involving 180 patients with SLE,who were divided into renal injury group(n=60)and non-renal injury group(n=120)based on presence or absence of renal involve-ment.The positive rates of ANA and anti-dsDNA and serum MCP-1 levels were compared between the two groups.Additionally,laboratory parameters were compared between anti-dsDNA-positive and anti-dsDNA-negative patients within the renal injury group.Pearson correlation analysis was used to assess the relationships between serum MCP-1 levels and renal function markers.Receiver operating characteristic(ROC)curves were constructed to evaluate the diagnostic performance of anti-dsDNA and MCP-1 for renal injury in SLE.Results There was no significant difference in the positive rate of ANA between the renal injury group(95.00％)and the non-renal injury group(91.67％)(P＞0.05).The positive rate of anti-dsDNA in the renal injury group(71.67％)was higher than that in the non-renal injury group(50.83％),and the serum MCP-1 level in the renal injury group was higher than that in the non-renal injury group,with statistically significant differences(P＜0.05).ROC curve analysis showed that the areas under the curves(AUCs)for anti-dsDNA and MCP-1 in diagnosing renal injury in SLE patients were 0.608(95％CI,0.522 to 0.695)and 0.668(95％CI,0.574 to0.762),respectively.The levels of hemoglobin(Hb),red blood cells(RBC),albumin(ALB),immunoglobulin A(IgA),immunoglobulin G(IgG)and complement C3 in patients in the renal injury group were all lower than those in patients in the non-renal injury group,the levels of red cell distribution width(RDW),β2-microglobulin(β2-MG),cystatin C(Cys-C),serum creat-inine(SCr),blood urea nitrogen(BUN)and uric acid(UA)were all higher than those in patients in the non-renal injury group,with statistically significant differences(P＜0.05).The levels ofβ2-MG,Cys-C,SCr,BUNand UA in anti-dsDNA-positive patients were all higher than those in an-ti-dsDNA-negative patients,with statistically significant differences(P＜0.05).Pearson correlation analysis results showed that serum MCP-1 levels in SLE patients with renal injury were significantly positively correlated with the levels of β2-MG,Cys-C,SCr,BUN and UA(r=0.711,0.684,0.593,0.402,0.441,P＜0.001).Conclusion Serum ANA has no significant association with renal injury in SLE patients,while positive anti-dsDNA and high expression of MCP-1 are closely re-lated to renal injury.The diagnostic efficacy of MCP-1 and anti-dsDNA for SLE renal injury is gen-eral.It is recommended to combine their detection with renal function indicators for a more accurate assessment of the degree of renal injury.关键词
抗核抗体/抗双链DNA抗体/单核细胞趋化蛋白-1/系统性红斑狼疮/狼疮性肾炎/肾损伤/β2-微球蛋白/胱抑素CKey words
antinuclear antibody/anti-double-stranded DNA antibody/monocyte chemoattrac-tant protein-1/systemic lupus erythematosus/lupus nephritis/renal injury/β2-microglobulin/cystatin C分类
医药卫生引用本文复制引用
党艳艳,韩双,王荣..抗核抗体、抗双链DNA抗体及单核细胞趋化蛋白-1与系统性红斑狼疮肾损伤的关系[J].实用临床医药杂志,2025,29(23):16-21,6.基金项目
国家自然科学基金项目(81931607) （81931607）
陕西省卫生健康委科研项目(2023SFR-10069) （2023SFR-10069）
