实用临床医药杂志2025，Vol.29Issue(23)：26-30,5.DOI:10.7619/jcmp.20254546
系统性红斑狼疮患者认知功能障碍与25-羟维生素D的相关性研究
Correlation between cognitive dysfunction and 25-hydroxyvitamin D in patients with systemic lupus erythematosus
摘要
Abstract
Objective To explore the correlation between cognitive dysfunction(CD)and the level of 25-hydroxyvitamin D[25(OH)D]in patients with systemic lupus erythematosus(SLE).Methods A total of 283 SLE patients were selected as the research subjects.According to the scores of the Montreal Cognitive Assessment Scale(MoC A),they were divided into cognitive-normal group(MoCA score≥26 points,145 cases)and cognitive-impairment group(MoCA score＜26 points,138 cases).Differences in demographic data,psychophysiological characteristics,disease activity,hor-mone treatment dosage,and 25(OH)D levels between the two groups were compared.Spearman cor-relation analysis was used to determine the correlation between MoCA scores and 25(OH)D levels,and multivariate logistic regression analysis was employed to investigate the association between 25(OH)D levels and the risk of CD.Results There were significant differences in age,Self-rating Depression Scale(SDS)scores,Fatigue Severity Scale(FSS)scores,dosage of hormone use,occupational sta-tus,educational level,and25(OH)D levels between the two groups(P＜0.05).The distribution differences in total MoCA scores and scores in each dimension between the two groups of SLE patients were also statistically significant(P＜0.05).Spearman correlation analysis showed that the 25(OH)D levels of CD patients were positively correlated with the abstract thinking ability scores(r=0.134,P=0.024),delayed recall scores(r=0.167,P=0.005),and total scores(r=0.167,P=0.005)in the MoCA.After adjusting for demographic data,psychophysiological characteristics,disease activity,and hormone use,multivariate logistic regression analysis revealed that 25(OH)D level for every 1 ng/mL increase,the risk of CD in patients decreased by 3％(OR=0.97,95％CI,0.95 to0.99,P=0.015).Conclusion The risk of CD in SLE patients is correlated with 25(OH)D levels.Maintaining a high level of 25(OH)D may have a protective effect.Clinically,its dynamic changes should be regularly monitored and timely interventions should be provided.关键词
系统性红斑狼疮/认知功能障碍/25-羟维生素D/蒙特利尔认知评估量表/维生素D缺乏/疾病活动度/激素使用量/多因素Logistic回归分析Key words
systemic lupus erythematosus/cognitive dysfunction/25-hydroxyvitamin D/Montreal Cognitive Assessment Scale/vitamin D deficiency/disease activity/dosage of hormone use/multivariate logistic regression analysis分类
医药卫生引用本文复制引用
卞文娟,徐任菊,朱昱璇,朱延通,邱茜叶,陈玉洁,李现文..系统性红斑狼疮患者认知功能障碍与25-羟维生素D的相关性研究[J].实用临床医药杂志,2025,29(23):26-30,5.基金项目
国家自然科学基金项目(82302040) （82302040）
南京大学医学院附属鼓楼医院护理科研立项项目(2025-A1155) （2025-A1155）
