实用临床医药杂志2025，Vol.29Issue(24)：36-42,7.DOI:10.7619/jcmp.20255510
振动正压呼气训练联合N-乙酰半胱氨酸雾化吸入对慢性阻塞性肺疾病急性加重期患者呼吸功能的影响
Effects of vibratory positive expiratory pressure training combined with nebulized N-acetylcysteine inhalation on respiratory function in patients with acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the effects of vibratory positive expiratory pressure training combined with nebulized N-acetylcysteine inhalation on respiratory function in patients with acute exac-erbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 53 patients with AECOPD were selected and randomly divided into control group(28 cases)and experimental group(25 cases).The control group received nebulized N-acetylcysteine inhalation therapy,while the ex-perimental group received vibratory positive expiratory pressure training in addition to nebulized inhala-tion.The cough symptom score,dyspnea score,blood gas analysis indicators,exercise tolerance,and pulmonary function indicators were compared between the two groups after 7 days of intervention.Results After 7 days of intervention,the cough symptom score and dyspnea score in the experimental group were significantly lower than those in the control group;the arterial partial pressure of oxygen[pa(O2)]was significantly higher in the experimental group than in the control group,while the ar-terial partial pressure of carbon dioxide[pa(CO2)]was significantly lower;the improvement in the five-repetition sit-to-stand test in the experimental group was(2.01±1.13)s,which was signifi-cantly greater than[(1.17±0.76)s]in the control group,with a statistically significant difference(P＜0.05).There was no statistically significant difference in pulmonary function indicators between the two groups(P＞0.05).Conclusion Vibratory positive expiratory pressure training combined with nebulized inhalation can effectively promote the clearance of airway secretions,im-prove dyspnea and oxygenation status,and enhance the degree of improvement in exercise tolerance in patients with AECOPD.关键词
慢性阻塞性肺疾病/振动正压呼气训练/主动循环呼吸技术/雾化吸入/N-乙酰半胱氨酸/呼吸功能/气道廓清/运动耐力Key words
chronic obstructive pulmonary disease/vibratory positive expiratory pressure training/active cycle of breathing technique/nebulized inhalation/N-acetylcysteine/respiratory function/airway clearance/exercise tolerance分类
医药卫生引用本文复制引用
朱亚兰,许勤,曹丽君,毕岑,张衎,陶笑,王萍..振动正压呼气训练联合N-乙酰半胱氨酸雾化吸入对慢性阻塞性肺疾病急性加重期患者呼吸功能的影响[J].实用临床医药杂志,2025,29(24):36-42,7.基金项目
国家自然科学基金资助项目(82200031) （82200031）
2023年度苏州市立医院护理科研项目(Slyyhl202306) （Slyyhl202306）
