检验医学与临床2026，Vol.23Issue(1)：49-56,8.DOI:10.3969/j.issn.1672-9455.2026.01.009
柴银亚甲方治疗风热痰阻型亚急性甲状腺炎的疗效及对疼痛因子、免疫功能指标、甲状腺功能指标的影响
Effect of Chaiyinya sub-party A in the treatment of subacute thyroiditis with wind,heat and phsputum obstruction and its influence on pain factors,immune function indexes and thyroid function indexes
摘要
Abstract
Objective To analyze the efficacy of Chaiyinya sub-party A in the treatment of subacute thy-roiditis with wind,heat and phsputum obstruction and its influence on pain factors,immune function indexes and thyroid function indexes.Methods A total of 100 patients with subacute thyroiditis admitted to the hospi-tal from July 2023 to July 2024 were selected as the research objects,and they were divided into the basic group and the Chaiyin sub-party A group by random number table method,with 50 cases in each group.The basic treatment group was treated with conventional western medicine,and the Chaiyin sub-party A group was treated with Chaiyin sub-party A on the basis of the basic treatment group.The basic treatment group and Chaiyin sub-party A group were treated for 4 weeks.After the treatment,the clinical efficacy was compared between the basic group and the Chaiyin sub-party A group.The scores of TCM syndromes(fever,sore throat,neck enlargement,headache,thyroid pain,hoarseness)were compared between the basic group and the Chaiyin sub-party A group before and after treatment.The levels of immune function indexes[complement C3,immunoglobulin(Ig)A,amyloid A(SAA),tumor necrosis factor(TNF)-β]and pain factors[serum pros-taglandin E2(E2),bradykinin]were detected in all patients.The levels of inflammatory indicators and thyroid function indicators[thyroid stimulating hormone(TSH),free thyroxine(FT4),thyroglobulin antibody(TgAb),free triiodothyronine(FT3)]were detected in all patients.The swelling time and pain resolution time of all patients were recorded.The adverse reactions of all patients during treatment were recorded.All patients were followed up for 3 months after treatment,and the recurrence of all patients was recorded.Results In the basic group,2 cases dropped out,and 48 cases were finally included.In Chaiyin sub-party A group,3 cases dropped out,and 47 cases were finally included.The total effective rate of Chaiyin sub-party A group was 95.74%,which was higher than 79.17%of the basic group,and the difference was statistically sig-nificant(P<0.05).After treatment,the scores of fever,sore throat,anterior neck swelling,headache,thyroid pain and hoarseness in the basic group and the Chaiyin sub-party A group were lower than those before treat-ment,and the scores of fever,sore throat,anterior neck swelling,headache,thyroid pain and hoarseness in the Chaiyin sub-party A group were lower than those in the basic group,and the differences were statistically sig-nificant(P<0.05).After treatment,the levels of complement C3,IgA,SAA,TNF-β in the basic group and the Chaiyin sub-party A group were lower than those before treatment,and the levels of complement C3,IgA,SAA,TNF-β in the Chaiyin sub-party A group were lower than those in the basic group,and the differences were statistically significant(P<0.05).The levels of E2,bradykinin in the basic group and the Chaiyin sub-party A group after treatment were lower than those before treatment,and the levels of E2 bradykinin in the Chaiyin sub-party A group after treatment were lower than those in the basic group,and the differences were statistically significant(P<0.05).After treatment,the levels of FT4,TgAb and FT3 in the basic group and the Chaiyin sub-party A group were lower than those before treatment,and the levels of FT4,TgAb and FT3 in the Chaiyin sub-party A group were lower than those in the basic group,and the differences were statistical-ly significant(P<0.05).The TSH level of the basic group and the Chaiyin sub-party A group after treatment was higher than that before treatment,and the TSH level of the Chaiyin sub-party A group after treatment was higher than that of the basic group,and the differences were statistically significant(P<0.05).After treatment,the swelling time and pain subsiding time of the Chaiyin sub-party A group were shorter than those of the basic group,and the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in the basic group and the Chaiyin sub-party A group during the treatment.After 3 months of follow-up,the recurrence rate of Chaiyin sub-party A group(2.13%)was lower than that of basic group(16.67%),and the difference was statistically significant(P<0.05).Conclusion Chaiyin sub-party A in the treatment of subacute thyroiditis can decrease the levels of inflammatory factors and pain factors,regulate immune func-tion,improve thyroid function,improve clinical efficacy,with low recurrence rate and high safety.关键词
柴银亚甲方/亚急性甲状腺炎/甲状腺功能/炎症因子/疼痛因子/免疫功能Key words
Chaiyin sub-party A/subacute thyroiditis/thyroid function/inflammatory factor/pain factor/immune function分类
医药卫生引用本文复制引用
邵帅,孙佳佳,石天昱,张军..柴银亚甲方治疗风热痰阻型亚急性甲状腺炎的疗效及对疼痛因子、免疫功能指标、甲状腺功能指标的影响[J].检验医学与临床,2026,23(1):49-56,8.基金项目
河北省中医药管理局科研计划项目(2021400). （2021400）
