检验医学与临床2026，Vol.23Issue(1)：57-62,6.DOI:10.3969/j.issn.1672-9455.2026.01.010
子宫内膜息肉组织中COX-2、Pten、Pax2蛋白表达情况及其与患者术后早期复发的关系
Expression of COX-2,Pten and Pax2 protein in endometrial polyps and their relationship with early recurrence after operation
摘要
Abstract
Objective To investigate the expression of cyclooxygenase(COX)-2,phosphatase and tensin homologue(Pten)and paired box gene 2(Pax)in patients with endometrial polyps(EP)and their relation-ship with early recurrence after operation.Methods A total of 187 EP patients admitted to the hospital from January 2021 to October 2023 were selected as the research objects.Their polyps and adjacent normal tissues were collected after admission,and the expressions of COX-2,Pten and Pax2 protein in the tissues were detec-ted by immunohistochemistry.The EP patients were followed up for 6 months after surgery,and the they were divided into recurrence group and non-recurrence group according to whether they recurred early after surgery.Multivariate Logistic regression was used to analyze the influencing factors of early postoperative re-currence in EP patients.Results The positive rate of COX-2 protein expressions in EP patients'polyps was higher than that in normal tissues adjacent to polyps,and the positive rates of Pten and Pax2 protein expres-sions were lower than those in normal tissues adjacent to polyps,and the differences were statistically signifi-cant(P<0.05).The positive rate of COX-2 protein expressions in EP patients polyp tissues with body mass index(BMI)>24 kg/m2 was higher than that in EP patients polyp tissues with BMI≤24 kg/m2,and the positive rates of Pten and Pax2 protein expressions were lower than those in EP patients polyp tissue with BMI≤24 kg/m2,and the differences were statistically significant(P<0.05).There were 47 cases in the re-currence group and 140 cases in the non-recurrence group.The proportion of BMI>24 kg/m2 and the positive rate of COX-2 protein expressions in polyp tissue of the recurrence group were higher than those of the non-recurrence group,and the positive rates of Pten and Pax2 protein expressions were lower than those of the non-recurrence group,and the differences were statistically significant(P<0.05).Multivariate Logistic re-gression analysis showed that BMI>24 kg/m2,COX-2 protein expressions positive and Pten and Pax2 protein expressions negative were risk factors for early postoperative recurrence in EP patients(P<0.05).Conclusion The positive rate of COX-2 protein expressions in the polyp tissue of EP patients is higher than that in the adjacent normal tissue,and the positive rates of Pten and Pax2 protein expressions are lower than that in the adjacent normal tissue,which are related to the early postoperative recurrence.关键词
子宫内膜息肉/环氧合酶-2/磷酸酶与张力蛋白同源物基因/配对盒基因2/临床参数/复发Key words
endometrial polyps/cyclooxygenase-2/phosphatase and tensin homolog gene/paired box gene 2/clinical parameter/relapse分类
医药卫生引用本文复制引用
张海燕,李红,房秋霞,吴聪哲,白惠..子宫内膜息肉组织中COX-2、Pten、Pax2蛋白表达情况及其与患者术后早期复发的关系[J].检验医学与临床,2026,23(1):57-62,6.基金项目
河北省医学科学研究课题计划(20241373). （20241373）
