检验医学与临床2026，Vol.23Issue(1)：95-100,6.DOI:10.3969/j.issn.1672-9455.2026.01.016
脂代谢指标与不明原因不孕患者胚胎质量及辅助生育结局的关系
Relationship between lipid metabolism indexes and embryo quality and assisted reproductive outcomes in patients with unexplained infertility
摘要
Abstract
Objective To investigate the relationship between lipid metabolism indexes[total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]and embryo quality and assisted reproductive outcomes in patients with unexplained infertility(UI).Methods A total of 201 UI patients admitted to the hospital from June 2021 to June 2023 were selected as the research objects.According to the outcome of assisted reproductive technology,the patients were divid-ed into success group and failure group.The baseline data,embryo quality and the levels of TC,TG,HDL-C and LDL-C were compared between the success group and the failure group.Pearson correlation analysis was used to analyze the correlation between TC,TG,HDL-C,LDL-C levels and the number of high-quality embry-os in UI patients.Multivariate Logistic regression was used to analyze the influencing factors of the failure of assisted reproductive outcomes in UI patients.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of TC,TG,HDL-C and LDL-C for the failure of assisted reproductive outcomes.Results Among 201 UI patients,10 were lost to follow-up,76 had pregnancy failure and 115 had successful pregnancy.The body mass index(BMI)of the failure group was higher than that of the success group,the lev-els of TG,TC and LDL-C were higher than those of the success group,the number of high-quality embryos was less than that of the success group,and the levels of estradiol(E2),progesterone(P)and HDL-C were lower than those of the success group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the levels of TG,TC and LDL-C were negatively correlated with the number of high-quality embryos(P<0.05),and the level of HDL-C was positively correlated with the number of high-quality embryos(P<0.05).Multivariate Logistic regression analysis showed that the increased levels of BMI,TG,TC and LDL-C were risk factors for the failure of assisted reproductive outcomes in UI patients,and the increased levels of E2,P and HDL-C were protective factors for the failure of assisted reproductive out-comes in UI patients(P<0.05).Logistic regression equation was used to fit BMI,P and E2 into model 1,and BMI,P,E,TG,TC,LDL-C and HDL-C into model 2 to draw ROC curve.The results showed that the AUC of model 2(0.920)was higher than that of model 1(0.856),and the difference was statistically significant(Z=3.341,P<0.05).Conclusion TG,TC,LDL-C and HDL-C are closely related to embryo quality and assisted reproductive outcomes in UI patients,which have added value in the prediction of assisted reproductive out-comes and are beneficial to clinical treatment decision-making.关键词
不明原因不孕/高密度脂蛋白胆固醇/总胆固醇/甘油三酯/低密度脂蛋白胆固醇/胚胎质量/生育结局Key words
unexplained infertility/high density lipoprotein cholesterol/total cholesterol/triglycer-ide/low density lipoprotein cholesterol/quality of embryos/reproductive outcome分类
医药卫生引用本文复制引用
司凡,王会男,陆宏艳,许丽丽,冯琳..脂代谢指标与不明原因不孕患者胚胎质量及辅助生育结局的关系[J].检验医学与临床,2026,23(1):95-100,6.基金项目
河北省承德市科技计划自筹经费项目(202301A015). （202301A015）
