检验医学与临床2026，Vol.23Issue(1)：101-105,111,6.DOI:10.3969/j.issn.1672-9455.2026.01.017
Er:YAG激光在糖尿病肾病并发牙周炎中的应用及对牙周状态、肾功能、龈沟液炎症因子的影响
Application of Er:YAG laser in diabetic nephropathy complicated with periodontitis and its effect on periodontal status,renal function and inflammatory factors in gingival crevar-fluid
摘要
Abstract
Objective To investigate application of Er:YAG laser in diabetic nephropathy complicated with periodontitis and its effect on periodontal status,renal function and inflammatory factors in gingival crevar-fluid.Methods A total of 124 patients with diabetic nephropathy complicated with periodontitis admitted to the hospital from April 2021 to November 2024 were selected as the research objects.According to the treat-ment methods,all patients were divided into the basic group and the laser group,with 62 cases in each group.The basic treatment group was given basic periodontal treatment,and the laser group was given Er:YAG laser treatment on the basis of the basic treatment.The clinical efficacy,periodontal status-related indicators[pro-bing depth(PD),modified sulcus bleeding index(mSBI),tooth mobility(TM),clinical attachment loss(CAL)],renal function and blood glucose indicators[blood urea nitrogen(BUN),serum creatinine(SCr),glycosylated hemoglobin(HbA1c)],Inflammatory factors in gingival crevicular fluid[tumor necrosis factor(TNF)-α,matrix metalloproteinase(MMP)-8,intercellular adhesion molecule(ICAM)-1]were compared between the basic group and the laser group.Results The total effective rate of laser group was higher than that of basic group,and the difference was statistically significant(P<0.05).The levels of SCr,BUN,HbA1c,TNF-α,MMP-8 and ICAM-1 in the basic group and laser group after treatment were lower than those before treatment,and the levels of PD,mSBI,TM and CAL in the laser group after treatment were lower than those in the basic group,the levels of TNF-α,MMP-8 and ICAM-1 in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Er:YAG laser combined with periodontal initial therapy in the treatment of diabetic nephropathy complicated with peri-odontitis can improve the gingival symptoms,reduce the inflammatory response,and promote the recovery of patients.关键词
Er:YAG激光治疗/牙周基础治疗/糖尿病肾病/牙周炎/炎症反应Key words
Er:YAG laser treatment/initial periodontal treatment/diabetic nephropathy/periodon-titis/inflammatory response分类
医药卫生引用本文复制引用
么远,曹佳佳,殷悦,赵志宇,毕磊,卢娜,张春光..Er:YAG激光在糖尿病肾病并发牙周炎中的应用及对牙周状态、肾功能、龈沟液炎症因子的影响[J].检验医学与临床,2026,23(1):101-105,111,6.基金项目
河北省医学科学研究课题计划(20201233). （20201233）
