辽宁中医药大学学报2026，Vol.28Issue(1)：34-38,5.DOI:10.13194/j.issn.1673-842X.2026.01.007
基于肠-肺轴理论探讨桑皮止咳方对呼吸道合胞病毒感染后咳嗽小鼠肠道菌群及代谢产物短链脂肪酸的影响
Study on the Effects of Sangpi Zhike Decoction(桑皮止咳方)on Intestinal Microbiota and Short-Chain Fatty Acid Metabolites in Mice with Post-RSV Infection Cough Based on the"Gut-Lung Axis"Theory
摘要
Abstract
Objective In this study,we investigated the therapeutic effect of Sangpi Zhike Decoction(桑皮止咳方)on a mouse model of cough caused by respiratory syncytial virus(RSV)infection,and analyzed its regulatory effect on intestinal microbes and short-chain fatty acids(SCFAs)levels based on the"lung and large intestine phases"and the theory of"gut-lung axis"in modern medicine.Methods In this study,60 female BALB/c mice were selected,and the experimental groups included blank control group,RSV infection model group,western medicine treatment group,and Sangpi Zhike Decoction low,medium and high dose treatment groups,each group included 10 mice.Except for the blank control group,the mice in the other groups were treated with RSV nasal drops to establish a cough model,and the cough response was further induced by capsaicin atomization.The general state of mice was recorded,and the morphological changes of lung and intestinal tissues were evaluated by HE staining.In addition,in order to deeply analyze the changes of intestinal microbiota,fecal samples were collected from the cecum,and the number of enterococci,lactobacilli and bifidobacteria in the group was quantitatively analyzed by selecting the medium,and the content of common SCFAs in the feces was determined by gas chromatography.Results Compared with the blank group,the mice in the model group showed obvious symptoms of respiratory tract diseases and pathological changes in lung and intestinal tissues.The level of intestinal flora decreased significantly(P＜0.01,P＜0.05)and the level of corresponding metabolites SCFAs decreased significantly(P＜0.01,P＜0.05).Conclusion Sangpi Zhike Decoction can not only alleviate respiratory symptoms such as cough in mice,but also regulate the gut microbiota abundance in model mice,restoring it to normal levels.This decoction treats post-infection cough through lung-intestine coordinated therapy.This study provides a scientific basis for the application of Sangpi Zhike Decoction in treating post-RSV infection cough in children under the"lung-intestine co-treatment"approach.关键词
桑皮止咳方/肠-肺轴/呼吸道合胞病毒/感染后咳嗽/肠道菌群/短链脂肪酸Key words
Sangpi Zhike Decoction(桑皮止咳方)/gut-lung axis/respiratory syncytial virus/post-infection cough/intestinal flora/short-chain fatty acids分类
医药卫生引用本文复制引用
李柯霖,刘智慧,王婧婕,索闯,白晓红,吕启慧,修婵..基于肠-肺轴理论探讨桑皮止咳方对呼吸道合胞病毒感染后咳嗽小鼠肠道菌群及代谢产物短链脂肪酸的影响[J].辽宁中医药大学学报,2026,28(1):34-38,5.基金项目
国家中医药管理局科研基金项目(0686-2211CA080200Z) （0686-2211CA080200Z）
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023036) （zyyzdxk-2023036）
辽宁省教育厅科学研究项目(LJKMZ20221334) （LJKMZ20221334）
辽宁省自然科学基金项目(20170540625) （20170540625）
辽宁省名中医传承工作室项目(辽中医药综合字[2024]19号) （辽中医药综合字[2024]19号）
