中南医学科学杂志2026，Vol.54Issue(1)：44-47,4.DOI:10.15972/j.cnki.43-1509/r.2026.01.009
射血分数降低的心力衰竭患者血清可溶性ST2、BNP水平动态变化及其对预后的预测价值
Dynamic changes of serum soluble ST2 and BNP levels in heart failure patients with reduced ejection fraction and their predictive value on prognosis
摘要
Abstract
Aim To explore the dynamic changes of serum soluble suppression of tumorigenicity 2(sST2)and brain natri-uretic peptide(BNP)levels and their predictive value on prognosis in heart failure patients with reduced ejection fraction(HFrEF).Methods Totally 80 patients with HFrEF were selected as the HFrEF group and were further divided into the grade Ⅱ heart function group(n=27),grade Ⅲ heart function group(n=26),and grade Ⅳ heart function group(n=27)based on their heart function clas-sification upon admission.Additionally,35 healthy individuals undergoing physical examinations were selected as the control group.The HFrEF group was further divided into the good prognosis group(66 cases)and the poor prognosis group(14 cases)based on the follow-up results.General data of the HFrEF group and the control group were compared.Serum sST2 and BNP levels in the grade Ⅱ heart function group,grade Ⅲ heart function group,grade Ⅳ heart function group,and the control group were compared.Serum sST2 and BNP levels at different points in the good prognosis group and the poor prognosis group were compared.Spearman correla-tion analysis was used to analyze the relationship between heart function classification and serum sST2 and BNP levels in HFrEF pa-tients.ROC curve analysis was used to analyze the predictive value of serum sST2 and BNP levels for the prognosis of HFrEF pa-tients.Results The proportion of patients with HFrEF combined with hypertension and diabetes were higher than those of the con-trol group(P<0.05),while LVEF was lower than that of the control group(P<0.05).The levels of serum sST2 and BNP in differ-ent heart function classification groups were significantly higher than those in the control group(P<0.05),and the levels of sST2 and BNP were increased with the increase of heart function classification(P<0.05).The results of Spearman correlation analysis showed that the heart function classification of HFrEF patients was positively correlated with the levels of serum sST2 and BNP(P<0.001).At admission,discharge,1-month follow-up,3-month follow-up,and 6-month follow-up,the levels of serum sST2 and BNP in the good prognosis group and the poor prognosis group showed a decreasing trend(P<0.05),and the levels of sST2 and BNP in the poor prognosis group were higher than those in the good prognosis group at the same time(P<0.05).The results of ROC curve showed that the combined predictive value of serum sST2 and BNP was higher than that of individual indicators(P<0.05).Conclusion The levels of serum sST2 and BNP are correlated with the cardiac function grading of HFrEF patients,and their combined monitoring has high predictive value for the prognosis of HFrEF patients.关键词
HFrEF/可溶性ST2/BNP/心功能分级/预后Key words
HFrEF/soluble ST2/BNP/classification of cardiac function/prognosis分类
医药卫生引用本文复制引用
戴禛,孟玙璠,戴果福..射血分数降低的心力衰竭患者血清可溶性ST2、BNP水平动态变化及其对预后的预测价值[J].中南医学科学杂志,2026,54(1):44-47,4.基金项目
国家自然科学基金资助项目(81904256) （81904256）
