中南医学科学杂志2026，Vol.54Issue(1)：67-70,4.DOI:10.15972/j.cnki.43-1509/r.2026.01.015
不同胰岛素给药方式对PCOS合并GDM患者血糖控制及妊娠结局的影响
Impact of different insulin administration methods on blood glucose control and pregnancy outcomes in patients with PCOS complicated by GDM
摘要
Abstract
Aim To explore the effects of different insulin administration methods on blood glucose control and pregnancy outcomes in patients with polycystic ovary syndrome(PCOS)complicated by gestational diabetes mellitus(GDM).Methods Pregnant women with GDM and PCOS who received insulin therapy were retrospectively selected.They were divided into three groups based on the initial insulin administration methods,namely continuous subcutaneous insulin infusion(CSII)group,multiple daily in-jections(MDI)group,and basal-bolus group,respectively.Glycated hemoglobin,time to achieve blood glucose targets,and inci-dence of perinatal complications were compared among the groups.Multivariate Logistic regression was used to analyze influencing factors for macrosomia.Results After treatment,all three groups showed significant improvements in these glucose metrics and a shorter time to achieve target glucose levels(P<0.05).The CSII group demonstrated superior improvements in glucose control and efficiency in reaching targets compared with the MDI and basal-bolus groups(P<0.05).The incidences of macrosomia,neonatal hy-poglycemia,and cesarean section were lower in the CSII group than those in the other two groups(P<0.05).Multivariate Logistic regression analysis indicated that the insulin treatment regimen was an independent influencing factor for macrosomia,with CSII serving as a significant protective factor(P<0.05).Conclusion CSII effectively optimizes glucose metabolic homeostasis in PCOS-GDM patients,reduces the risk of adverse pregnancy outcomes,and holds clinical promotion value.关键词
多囊卵巢综合征/妊娠期糖尿病/胰岛素泵/血糖控制/妊娠结局Key words
polycystic ovary syndrome/gestational diabetes mellitus/insulin pump/blood glucose control/pregnancy outcome分类
医药卫生引用本文复制引用
刘华美,刘亚佳..不同胰岛素给药方式对PCOS合并GDM患者血糖控制及妊娠结局的影响[J].中南医学科学杂志,2026,54(1):67-70,4.基金项目
河北省医学科学研究课题计划项目(20210207) （20210207）
