中南医学科学杂志2026，Vol.54Issue(1)：71-74,4.DOI:10.15972/j.cnki.43-1509/r.2026.01.016
血清ITLN-1、PCSK9和sCD163水平与急性缺血性脑卒中病情及预后的关系
Relationship between serum levels of ITLN-1,PCSK9,sCD163 and the disease severity and prognosis of acute ischemic stroke
摘要
Abstract
Aim To prospectively investigate the relationship between serum levels of intelectin-1(ITLN-1),proprotein convertase subtilisin/kexin type 9(PCSK9),and soluble CD163(sCD163)and disease severity as well as prognosis in acute ischemic stroke(AIS).Methods A total of 332 AIS patients(AIS group)were enrolled and divided into the mild(n=114),moderate(n=125),and severe(n=93)groups according to the National Institutes of Health Stroke Scale(NIHSS)score.Based on the modified Rankin Scale(mRS)score at 3 months after treatment,patients were classified into the poor prognosis(n=83)and good prognosis(n=249)groups.Additionally,332 healthy volunteers undergoing physical examinations during the same period were se-lected as the control group.Serum ITLN-1,PCSK9,and sCD163 levels and NIHSS scores were compared among the groups.Lo-gistic regression analysis was used to identify factors influencing prognosis,and receiver operating characteristic(ROC)curves with Z-test were applied to evaluate the predictive value of each indicator.Results Serum ITLN-1 levels were higher in the control group than those in the AIS group,higher in the mild group than those in the moderate and severe groups,and higher in the good prognosis group than those in the poor prognosis group.In contrast,PCSK9 and sCD163 levels were lower in the control group than those in the AIS group,lower in the mild group than those in the moderate and severe groups,and lower in the good prognosis group than those in the poor prognosis group.NIHSS scores were lower in the mild group than those in the moderate and severe groups and lower in the good prognosis group than those in the poor prognosis group(P<0.05).ITLN-1,PCSK9,and sCD163 were all independent factors influencing prognosis in AIS patients(P<0.05).The combined predictive value of the three indicators was higher than that of any single indicator(P<0.001).Conclusion AIS patients exhibit decreased serum ITLN-1 levels and increased PCSK9 and sCD163 levels.The combined detection of these three indicators provides good prognostic evaluation value for AIS patients.关键词
急性缺血性脑卒中/ITLN-1/PCSK9/sCD163/预后Key words
acute ischemic stroke/ITLN-1/PCSK9/CD163/prognosis分类
医药卫生引用本文复制引用
钱志楠,姜燕,吕金彤..血清ITLN-1、PCSK9和sCD163水平与急性缺血性脑卒中病情及预后的关系[J].中南医学科学杂志,2026,54(1):71-74,4.基金项目
河北省医学科学研究重点课题计划项目(20251243) （20251243）
