器官移植2026，Vol.17Issue(1)：9-15,7.DOI:10.12464/j.issn.1674-7445.2025232
抗原提呈细胞在异种移植中的作用研究进展
Research progress on the role of antigen-presenting cells in xenotransplantation
摘要
Abstract
Organ transplantation is an effective alternative treatment for patients with end-stage organ failure.However,the shortage of donor organs has limited the widespread application of clinical transplantation.In recent years,breakthroughs in CRISPR-Cas9 gene editing technology have overcome the barrier of hyperacute rejection in xenotransplantation,offering a potential solution to the organ shortage crisis.Rejection remains a critical factor affecting graft survival.Antigen-presenting cells play a vital role in the initiation and progression of rejection and immune regulation in xenotransplantation.Therefore,in-depth investigation into the role of antigen-presenting cells in xenotransplantation is of great significance.This article summarizes the roles and therapeutic strategies of professional antigen-presenting cells,including macrophages,dendritic cells and B cells in xenotransplantation,aiming to provide insights for future research on immune regulation mechanisms in this field.关键词
异种移植/排斥反应/抗原提呈细胞/巨噬细胞/树突状细胞/B细胞/免疫调控/免疫耐受Key words
Xenotransplantation/Rejection/Antigen-presenting cell/Macrophage/Dendritic cell/B cell/Immune regulation/Immune tolerance分类
医药卫生引用本文复制引用
水看看,周浩然,徐晔,罗秋琳,李腾芳,张和栋,彭龙开,代贺龙..抗原提呈细胞在异种移植中的作用研究进展[J].器官移植,2026,17(1):9-15,7.基金项目
中国工程科技发展战略湖南研究院2025年战略研究与咨询项目(2025WK1006) （2025WK1006）
国家科技重大专项(2025ZD0552202) （2025ZD0552202）
国家自然科学基金面上项目(82270796) （82270796）
