器官移植2026，Vol.17Issue(1)：28-35,8.DOI:10.12464/j.issn.1674-7445.2025252
异种移植免疫抑制方案研究进展与临床挑战
Research progress and clinical challenges in immunosuppressive regimens for xenotransplantation
摘要
Abstract
As a pivotal strategy to alleviate the shortage of organ donors,xenotransplantation has achieved remarkable advances in both pre-clinical and clinical studies in recent years,driven by continuous optimization of gene modification techniques and immunosuppressive regimens.Nevertheless,clinical translation still confronts formidable challenges,including rejection and heightened infection risks,which severely compromise long-term graft survival.Consequently,the role of immunosuppressive regimens in xenotransplantation has become increasingly prominent.This article summarizes the mechanisms underlying xenogeneic immune rejection,the latest developments in immunosuppressive regimens,cutting-edge strategies for inducing immune tolerance and the major hurdles facing clinical xenotransplantation.It delves into potential optimization strategies and directions for future clinical research,aiming to offer theoretical insights and practical guidance for the safe and effective application of clinical xenotransplantation.关键词
异种移植/排斥反应/感染/基因修饰/免疫抑制/免疫诱导/免疫耐受/免疫检查点抑制剂/基因治疗Key words
Xenotransplantation/Rejection/Infection/Gene modification/Immunosuppression/Immune induction/Immune tolerance/Immune-checkpoint inhibitor/Gene therapy分类
医药卫生引用本文复制引用
张宇,王崑,朱许源,陈羽翔,李涛,马晓杰,蒋鸿涛..异种移植免疫抑制方案研究进展与临床挑战[J].器官移植,2026,17(1):28-35,8.基金项目
国家重点研发计划(2024YFC3406800) （2024YFC3406800）
国家自然科学基金(82460153、82400891) （82460153、82400891）
海南省卫生健康科技创新联合项目(WSJK2025MS163) （WSJK2025MS163）
海南省级博士研究生创新课题(Qhyb2023-179、Qhys2023-430) （Qhyb2023-179、Qhys2023-430）
海南省优秀人才团队建设项目 （）
