器官移植2026，Vol.17Issue(1)：44-50,7.DOI:10.12464/j.issn.1674-7445.2025237
巨噬细胞在肾移植抗体介导的排斥反应中的作用及临床应用进展
The role and clinical application progress of macrophages in antibody-mediated rejection in kidney transplantation
摘要
Abstract
Kidney transplantation is the most effective treatment for end-stage renal failure,and antibody-mediated rejection remains the leading cause of late allograft loss.Macrophages,as central effectors of innate immunity,play a crucial role in the initiation,progression and tissue damage of antibody-mediated rejection.This article reviews the spatiotemporal dynamic evolution of macrophage polarization status in different stages of antibody-mediated rejection,the fine regulation of key signaling pathways for macrophage polarization,macrophage related molecules and the application prospects of targeted macrophage therapy.In depth analysis of the research progress of macrophages in antibody-mediated rejection,aiming to provide important theoretical basis for the development of precision diagnostic tools based on macrophages and novel immune intervention targets for antibody mediated rejection,ultimately promoting the improvement of long-term prognosis in kidney transplantation.关键词
巨噬细胞/肾移植/抗体介导的排斥反应/供者特异性抗体/干扰素-γ/炎症反应/纤维化/免疫治疗Key words
Macrophage/Kidney transplantation/Antibody-mediated rejection/Donor specific antibody/Interferon-γ/Inflammation/Fibrosis/Immunotherapy分类
医药卫生引用本文复制引用
汤寰,桂泽平,顾民,王子杰..巨噬细胞在肾移植抗体介导的排斥反应中的作用及临床应用进展[J].器官移植,2026,17(1):44-50,7.基金项目
国家自然科学基金(82470790、81900684) （82470790、81900684）
江苏省科技计划专项资金(重点研发计划社会发展)(BE2023784) （重点研发计划社会发展）
