器官移植2026，Vol.17Issue(1)：51-60,10.DOI:10.12464/j.issn.1674-7445.2025238
肝素结合蛋白在器官移植中的作用研究进展与临床应用前景
Research progress and clinical application prospects of heparin-binding protein in organ transplantation
摘要
Abstract
Heparin-binding protein(HBP)is a pro-inflammatory granule protein released by activated neutrophils,known for its role in modulating vascular permeability and its pathological significance in infectious diseases.In recent years,HBP has garnered attention due to its immune-activating effects in contexts such as sepsis,acute lung injury and organ transplantation.It has been proposed as a potential biomarker for early detection of infection and inflammation.While preliminary progress has been made in animal studies,clinical evidence remains limited.Therefore,this article focuses on the mechanism of action of HBP in transplantation-related complications,explores its potential pathways for predicting infection risk,mediating ischemia-reperfusion injury and rejection,and evaluates the feasibility of intervention strategies such as neutralizing antibodies,heparin derivatives and albumin.The pivotal role of HBP in regulating inflammatory responses post-transplant may offer a novel target for postoperative infection monitoring and personalized therapeutic interventions.关键词
肝素结合蛋白/器官移植/生物标志物/炎症反应/排斥反应/缺血-再灌注损伤/感染/免疫调控Key words
Heparin-binding protein/Organ transplantation/Biomarker/Inflammatory response/Rejection/Ischemia-reperfusion injury/Infection/Immune regulation分类
医药卫生引用本文复制引用
张程昶,李若竹,王叶岐鸣,代辰..肝素结合蛋白在器官移植中的作用研究进展与临床应用前景[J].器官移植,2026,17(1):51-60,10.基金项目
国家自然科学基金(81900368) （81900368）
